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1996-02-26
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Document 0192
DOCN M9620192
TI A back-calculation method to estimate the age and period HIV infection
intensity, considering the susceptible population.
DT 9602
AU Verdecchia A; Mariotto AB; Istituto Superiore di Sanita, Roma, Italy.
SO Stat Med. 1995 Jul 30;14(14):1513-30. Unique Identifier : AIDSLINE
MED/96000842
AB An extension of the back-calculation method to reconstruct the past
history of HIV infections is presented. In this method the HIV infection
intensity, as a function of age and calendar time, is assumed to belong
to a family of parametric functions and is back-calculated from the
observed AIDS incidence cases, knowledge of the incubation period and of
the susceptible population, the final model being chosen as the one that
gives the best fit. The model allows for the interaction between age and
calendar time. The application to the main risk groups in Italy, male
IVDUs and homosexuals, showed that age and the susceptible population
were important in estimating the epidemic among IVDUs; interaction
between age and calendar time was found to be significant, showing that
among young IVDUs the risk of infection decreased faster than among
older IVDUs. Sensitivity of the estimates to the assumption of
population and choice of the infection function is investigated.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/TRANSMISSION Adult
Cohort Studies Disease Outbreaks/*STATISTICS & NUMER DATA Female
Homosexuality, Male/STATISTICS & NUMER DATA Human HIV
Infections/*EPIDEMIOLOGY/TRANSMISSION HIV Seroprevalence/*TRENDS
Italy/EPIDEMIOLOGY Male Models, Statistical Risk Factors Substance
Abuse, Intravenous/EPIDEMIOLOGY Support, Non-U.S. Gov't JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).