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M9620257.TXT
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1996-02-26
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Document 0257
DOCN M9620257
TI The effects of human immunodeficiency virus infection on macrophage
phagocytosis of Candida.
DT 9602
AU Eversole LR; Fleischmann J; Baldwin GC; Sapp JP; Section of Diagnostic
Sciences, University of California at Los; Angeles, School of Dentistry
90024, United States.
SO Oral Microbiol Immunol. 1994 Feb;9(1):55-9. Unique Identifier : AIDSLINE
MED/96073171
AB The effects of infection by human immunodeficiency virus (HIV) on
phagocytic function towards Candida pseudotropicalis were tested using
monocytotropic and nonmonocytotropic HIV strains on peripheral blood
monocytes. There were no differences in either quantitative phagocytic
activity or efficacy between the two infected and control mock-infected
monocytes. Immunofluorescence for cytoplasmic p24 antigen and in situ
hybridization for detection of HIV-specific RNA sequences revealed that
very few cells (10(-4)) exhibit productive infection. Occasional cells
with active infection as defined by microscopically detectable
fluorescence labelling contained phagocytized yeasts.
DE AIDS-Related Opportunistic Infections/IMMUNOLOGY
Candida/*IMMUNOLOGY/ISOLATION & PURIF
Candidiasis/COMPLICATIONS/IMMUNOLOGY Cells, Cultured Comparative Study
Human HIV/*IMMUNOLOGY/ISOLATION & PURIF HIV
Infections/COMPLICATIONS/*IMMUNOLOGY
Macrophages/IMMUNOLOGY/MICROBIOLOGY Monocytes/IMMUNOLOGY/MICROBIOLOGY
*Phagocytosis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).