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1996-02-26
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Document 0260
DOCN M9620260
TI Imaging infection and inflammation in an African environment: comparison
of 99Tcm-HMPAO-labelled leukocytes and 67Ga-citrate.
DT 9602
AU Bester MJ; Van Heerden PD; Klopper JF; Wasserman HJ; Rubow S; de Klerk
F; Department of Nuclear Medicine, Tygerberg Hospital, South Africa.
SO Nucl Med Commun. 1995 Jul;16(7):599-607. Unique Identifier : AIDSLINE
MED/96078733
AB A considerable segment of the population of South Africa has a disease
spectrum similar to those of the industrialized countries. However, a
much larger proportion of its inhabitants comes from historically
disadvantaged communities and is plagued by diseases typical of the
developing world. Infectious diseases head the list as a cause of
mortality in certain age groups. We have studied 108 patients presenting
with a wide array of infections. Fifty-eight patients were examined with
67Ga-citrate and with 99Tcm-HMPAO-labelled leukocytes, 40 with
leukocytes alone and 10 who had a high pre-test probability of
tuberculosis with 67Ga only. The sensitivity and specificity of
99Tcm-labelled leukocyte scintigraphy in the 58 patients who had both
studies were 89 and 84%, respectively, while the corresponding values
for 67Ga scintigraphy were 81 and 74%, respectively. The overall
sensitivity and specificity for 99Tcm-labelled leukocytes for detecting
inflammatory sites in all 98 cases were 92 and 89%, respectively.
Although labelled leukocytes were the better of the two agents for the
early diagnosis of infections with a high probability of neutrophil
infiltration, 67Ga remains an excellent alternative. It is the first
choice in patients in whom tuberculosis or a neoplastic process is
suspected as a cause of fever. It is also safer to use in areas where
labelling of leukocytes is inadvisable because of inadequate sterility
or where the risk is high of infecting other patients or staff with HIV.
DE Adolescence Adult Age Factors Aged Child Child, Preschool Citrates
Communicable Diseases/*RADIONUCLIDE IMAGING Comparative Study Gallium
Radioisotopes/*DIAGNOSTIC USE/PHARMACOKINETICS Human Infant
*Leukocytes Middle Age Organotechnetium Compounds/*DIAGNOSTIC
USE/PHARMACOKINETICS Oximes/*DIAGNOSTIC USE/PHARMACOKINETICS South
Africa Tissue Distribution JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).