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1996-02-26
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Document 0262
DOCN M9620262
TI Zinc and immune function.
DT 9602
AU Ripa S; Ripa R; Istituto di Clinica Medica Generale, Universita di
Ferrara.
SO Minerva Med. 1995 Jul-Aug;86(7-8):315-8. Unique Identifier : AIDSLINE
MED/96069696
AB Zinc and immune function relationship has been extensively studied. Both
in experimentally induced mineral deficit and in genetically determined
deficit observable in acrodermatitis enteropathica and in enteropathy of
Danish A-46 cattle, a B and T dependent antibody response decrease, a T
dependent cytolytic response decrease and a natural killer cytotoxic
activity decrease are present noteviously. Serious reduction of the
immune function is present, in proportion to the value of low zinc
plasmatic level, in elderly patients, in malnourished and seriously zinc
deficient children, in patients subjected to total parenteral supply, in
HIV infections and especially in evident AIDS: in this condition the
plasmatic zinc level can be considered, together with the CD4+
lymphocytes amount and the B2-microglobulin value, a disease progression
marker. Zinc immunostimulating action mechanisms are complex, although
thymic hormone (of which zinc is essential cofactor) stimulation seems
to be most important. Zinc supplementation, also parenterally, can be
useful in immunodeficiency (in the elderly, in the post-surgical
patients, in genetically determined or alimentary induced deficit, in
AIDS.
DE Acquired Immunodeficiency Syndrome/BLOOD Age Factors Aged Animal
Autoimmune Diseases/BLOOD/ETIOLOGY Cattle Child Child Nutrition
Disorders/BLOOD/ETIOLOGY/PREVENTION & CONTROL Human *Immunity
Immunologic Diseases/BLOOD/ETIOLOGY/PREVENTION & CONTROL
Zinc/ADMINISTRATION & DOSAGE/BLOOD/DEFICIENCY/*PHYSIOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).