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- Document 0265
- DOCN M9620265
- TI Spatial data analysis in the quantitative assessment of cerebral white
- matter pathology on MRI in HIV infection.
- DT 9602
- AU Corrigall RJ; Chong WK; Paley M; Wilkinson ID; Lantos P; Everall I;
- Maudsley Hospital, London, UK.
- SO Neuroradiology. 1995 Aug;37(6):429-33. Unique Identifier : AIDSLINE
- MED/96038430
- AB This study was carried out using MRI (proton density--and T2-weighted)
- on 16 HIV-negative controls, 9 symptom-free HIV-positive patients and 25
- with CDC IV HIV disease. The studies from this last group had previously
- been allocated by a radiologist to the following categories: 8 with
- focal mass lesions and normal-appearing white matter; 9 with diffuse
- encephalopathy (high signal on T2-weighted images, affecting most or all
- of the white matter) and 8 with patchy encephalopathy (high signal
- affecting only one or two areas within the white matter). Moran's I, a
- statistic of spatial autocorrelation, was calculated for the grey-scale
- values of a sampled pixel array from a central white matter region of
- each of the images. All values of Moran's I calculated in this study
- showed a large positive excess over the expected value under
- randomisation, indicating highly significant positive auto-correlation
- in the spatial arrangement of the grey-scale values. On T2-weighted
- images a statistically significant increase in the mean value of Moran's
- I, compared with controls, was found in the diffuse encephalopathy
- group, indicating that quantifiable changes in the spatial
- autocorrelation of pixel data can be related to recognised qualitative
- changes in the appearance of white matter in subjects with HIV disease.
- A lesser, but significant, rise in the mean value of Moran's I was also
- found in the focal mass lesion group, suggesting that changes in spatial
- autocorrelation may indicate pathological change in advance of
- qualitative MRI changes.
- DE AIDS Dementia Complex/*DIAGNOSIS Brain/*PATHOLOGY Cerebral
- Cortex/PATHOLOGY Cerebral Ventricles/PATHOLOGY Demyelinating
- Diseases/DIAGNOSIS Diagnosis, Differential Human *HIV-1 Magnetic
- Resonance Imaging/*METHODS Neuropsychological Tests JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-