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M9620265.TXT
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1996-02-26
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Document 0265
DOCN M9620265
TI Spatial data analysis in the quantitative assessment of cerebral white
matter pathology on MRI in HIV infection.
DT 9602
AU Corrigall RJ; Chong WK; Paley M; Wilkinson ID; Lantos P; Everall I;
Maudsley Hospital, London, UK.
SO Neuroradiology. 1995 Aug;37(6):429-33. Unique Identifier : AIDSLINE
MED/96038430
AB This study was carried out using MRI (proton density--and T2-weighted)
on 16 HIV-negative controls, 9 symptom-free HIV-positive patients and 25
with CDC IV HIV disease. The studies from this last group had previously
been allocated by a radiologist to the following categories: 8 with
focal mass lesions and normal-appearing white matter; 9 with diffuse
encephalopathy (high signal on T2-weighted images, affecting most or all
of the white matter) and 8 with patchy encephalopathy (high signal
affecting only one or two areas within the white matter). Moran's I, a
statistic of spatial autocorrelation, was calculated for the grey-scale
values of a sampled pixel array from a central white matter region of
each of the images. All values of Moran's I calculated in this study
showed a large positive excess over the expected value under
randomisation, indicating highly significant positive auto-correlation
in the spatial arrangement of the grey-scale values. On T2-weighted
images a statistically significant increase in the mean value of Moran's
I, compared with controls, was found in the diffuse encephalopathy
group, indicating that quantifiable changes in the spatial
autocorrelation of pixel data can be related to recognised qualitative
changes in the appearance of white matter in subjects with HIV disease.
A lesser, but significant, rise in the mean value of Moran's I was also
found in the focal mass lesion group, suggesting that changes in spatial
autocorrelation may indicate pathological change in advance of
qualitative MRI changes.
DE AIDS Dementia Complex/*DIAGNOSIS Brain/*PATHOLOGY Cerebral
Cortex/PATHOLOGY Cerebral Ventricles/PATHOLOGY Demyelinating
Diseases/DIAGNOSIS Diagnosis, Differential Human *HIV-1 Magnetic
Resonance Imaging/*METHODS Neuropsychological Tests JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).