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1996-02-26
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Document 0277
DOCN M9620277
TI A sex difference in the human brain and its relation to transsexuality
[see comments]
DT 9602
AU Zhou JN; Hofman MA; Gooren LJ; Swaab DF; Graduate School Neurosciences
Amsterdam, Netherlands Institute; for Brain Research, The Netherlands.
SO Nature. 1995 Nov 2;378(6552):68-70. Unique Identifier : AIDSLINE
MED/96061003
CM Comment in: Nature 1995 Nov 2;378(6552):15-6
AB Transsexuals have the strong feeling, often from childhood onwards, of
having been born the wrong sex. The possible psychogenic or biological
aetiology of transsexuality has been the subject of debate for many
years. Here we show that the volume of the central subdivision of the
bed nucleus of the stria terminals (BSTc), a brain area that is
essential for sexual behaviour, is larger in men than in women. A
female-sized BSTc was found in male-to-female transsexuals. The size of
the BSTc was not influenced by sex hormones in adulthood and was
independent of sexual orientation. Our study is the first to show a
female brain structure in genetically male transsexuals and supports the
hypothesis that gender identity develops as a result of an interaction
between the developing brain and sex hormones.
DE Acquired Immunodeficiency Syndrome/PATHOLOGY Adult Female
Homosexuality Human Hypothalamus/*ANATOMY & HISTOLOGY/PHYSIOLOGY Male
Sex Behavior Sex Characteristics Support, Non-U.S. Gov't
*Transsexualism JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).