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1996-02-26
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Document 0292
DOCN M9620292
TI Torsade de pointes and elevated magnesium and calcium requirements
associated with intravenous pentamidine.
DT 9602
AU Olree K; Stein-Gocken J
SO Nutr Clin Pract. 1994 Oct;9(5):191-5. Unique Identifier : AIDSLINE
MED/96037612
AB We present a report of markedly elevated calcium and magnesium
requirements in an AIDS patient receiving central venous nutrition.
These increased requirements were attributed to urinary magnesium losses
associated with intravenous pentamidine therapy. The combination of
intravenous pentamidine and electrolyte abnormalities resulted in the
development of the dysrhythmia, torsade de pointes, in the patient. A
review of literature presenting similar cases is included. Nutrition
practitioners should be aware of the often prolonged effect of
intravenous pentamidine on magnesium and calcium homeostasis so that
adequate supplementation will be provided, perhaps preventing the
development of life-threatening torsade de pointes.
DE Adult AIDS-Related Opportunistic Infections/DRUG THERAPY Case Report
Electrocardiography Human Hypocalcemia/*CHEMICALLY INDUCED Infusions,
Intravenous Magnesium Deficiency/BLOOD/*CHEMICALLY INDUCED Male
Nutritional Support Pentamidine/*ADVERSE EFFECTS Pneumonia,
Pneumocystis carinii/DRUG THERAPY Torsades de Pointes/*CHEMICALLY
INDUCED JOURNAL ARTICLE REVIEW REVIEW OF REPORTED CASES
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).