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1996-02-26
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Document 0294
DOCN M9620294
TI Cytomegalovirus retinitis in patients with AIDS: current status.
DT 9602
AU Luckie AP; Department of Ophthalmology, University of Melbourne, VIC.
SO Med J Aust. 1995 Nov 6;163(9):489-92. Unique Identifier : AIDSLINE
MED/96085000
AB About 20%-30% of patients with AIDS will develop cytomegalovirus (CMV)
retinitis when they are severely immunodeficient (CD4 cell count below
40 cells/microL). It causes extensive retinal damage with visual
deficits, and relapses are frequent. Intravenous ganciclovir and
foscarnet are standard therapy, but their high toxicity and long term
intravenous access mean that advances in treatment, including oral
prophylactic agents, intravitreal injections and surgical implants, may
provide a better quality of life for patients. Prophylactic
ophthalmological screening of patients with CD4 cell counts below 100
cells/microL to detect asymptomatic retinitis is needed.
DE Antiviral Agents/THERAPEUTIC USE *AIDS-Related Opportunistic
Infections/DIAGNOSIS/DRUG THERAPY *Cytomegalovirus
Retinitis/DIAGNOSIS/DRUG THERAPY Foscarnet/THERAPEUTIC USE
Ganciclovir/THERAPEUTIC USE Human JOURNAL ARTICLE REVIEW REVIEW,
ACADEMIC
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).