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M9620362.TXT
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1996-02-26
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Document 0362
DOCN M9620362
TI Correlation between AIDS-related Kaposi sarcoma histological grade and
in vitro behavior: reduced exogenous growth factor requirements for
isolates from high grade lesions.
DT 9602
AU Bailer RT; Lazo A; Ng-Bautista CL; Hout BL; Ness GM; Hegtvedt AK; Lantry
LE; Blakeslee JR; Stephens RE; Brierley GP; et al; Department of
Veterinary Pathobiology, Ohio State University,; Columbus, USA.
SO Lymphology. 1995 Sep;28(3):126-37. Unique Identifier : AIDSLINE
MED/96038359
AB Kaposi sarcoma, the most common AIDS-associated malignancy, affects
10-30% of all AIDS patients. To date, research into the biological
characteristics of AIDS-related Kaposi sarcoma (AIDS-KS) derived cell
lines has been based on cultures established from skin explants or
pleural effusions/peritoneal fluids. We have established several AIDS-KS
lines from biopsy confirmed oral mucosal and epidermal AIDS-KS lesions
and have found a correlation between AIDS-KS lesional grade and in vitro
cellular growth characteristics. In comparison to epidermal AIDS-KS
lesions, mucosal AIDS-KS lesions frequently possessed both a more
advanced histologic grade and demonstrated a greater capacity to
proliferate in minimal medium. We report the ability of AIDS-KS isolates
from high grade lesions to sustain proliferation (greater than 60
population doubling levels) in medium not supplemented with endothelial
cell growth supplement and/or cytokine rich conditioned medium. These
findings indicate that AIDS-KS cells isolated from high grade lesions
have reduced requirements for exogenously provided growth supplements,
and suggest that increased autologous cytokine production accompanies
AIDS-KS lesional progression.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Cell Cycle Cell Line
Culture Media Cytokines/BIOSYNTHESIS Human Male Mouth
Neoplasms/*PATHOLOGY Sarcoma, Kaposi's/ETIOLOGY/*PATHOLOGY Skin
Neoplasms/*PATHOLOGY Tumor Cells, Cultured JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).