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M9620375.TXT
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1996-02-26
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Document 0375
DOCN M9620375
TI Isolation of a highly cytopathic lentivirus from a nondomestic cat.
DT 9602
AU Barr MC; Zou L; Holzschu DL; Phillips L; Scott FW; Casey JW; Avery RJ;
Department of Microbiology and Immunology, College of Veterinary;
Medicine, Cornell University, Ithaca, New York 14853, USA.
SO J Virol. 1995 Nov;69(11):7371-4. Unique Identifier : AIDSLINE
GENBANK/U31349
AB A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a
Pallas' cat (Otocolobus manul) is highly cytopathic in CrFK cells, in
contrast to the chronic, noncytolytic infection established by an FIV
isolate from a domestic cat (FIV-Fca). The virions have typical
lentivirus morphology, density, and magnesium-dependent reverse
transcriptase activity. The major core protein is antigenically
cross-reactive with that of FIV-Fca; however, FIV-Oma transcripts do not
cross-hybridize with FIV-Fca. A conserved region of the FIV-Oma pol gene
has 76 to 80% nucleic acid identify with the corresponding pol regions
of other feline lentiviruses and 64 to 69% identity with those of human,
ovine, and equine lentiviruses.
DE Animal Animals, Wild Base Sequence Blotting, Northern
Carnivora/*VIROLOGY Case Report Cats Cell Line Comparative Study
Conserved Sequence Genes, pol Horses Human Immunodeficiency Virus,
Feline/*CLASSIFICATION/*ISOLATION & PURIF/ ULTRASTRUCTURE
Lentivirus/*CLASSIFICATION/GENETICS/ISOLATION & PURIF Male Microscopy,
Electron Molecular Sequence Data RNA-Directed DNA Polymerase/ANALYSIS
RNA, Messenger/ISOLATION & PURIF RNA, Viral/ISOLATION & PURIF Sheep
Support, Non-U.S. Gov't Virion/ULTRASTRUCTURE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).