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1996-02-26
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Document 0378
DOCN M9620378
TI Cell cycle dependence of foamy retrovirus infection.
DT 9602
AU Bieniasz PD; Weiss RA; McClure MO; Department of GU Medicine and
Communicable Diseases, Jefferiss; Research Trust, St. Mary's Hospital
Medical School, London,; United Kingdom.
SO J Virol. 1995 Nov;69(11):7295-9. Unique Identifier : AIDSLINE
MED/96013840
AB In common with oncoviruses but unlike the lentivirus human
immunodeficiency virus type 1, foamy (spuma) viruses require host cell
proliferation for productive infection. We show that human
immunodeficiency virus type 1 replicates in RD-CD4 cells regardless of
the growth arrest condition of the cells, while murine leukemia virus is
unable to infect growth-arrested RD-CD4 cells or cells progressing
through a partial cell cycle that includes S phase but not mitosis.
Human foamy virus, like murine leukemia virus, does not productively
infect G1/S or G2 growth-arrested cells. Two other foamy viruses, simian
foamy virus type 1, isolated from a macaque, and simian foamy virus type
6, isolated from a chimpanzee, also fail to establish productive
infection in G1/S-arrested cells.
DE Animal Aphidicolin/PHARMACOLOGY *Cell Cycle/DRUG EFFECTS/RADIATION
EFFECTS Cell Division Cell Line Chimpansee troglodytes/VIROLOGY
Comparative Study CD4-Positive T-Lymphocytes/VIROLOGY G1 Phase G2
Phase Human HIV-1/*PHYSIOLOGY/PATHOGENICITY Leukemia Viruses,
Murine/PHYSIOLOGY Macaca/VIROLOGY Species Specificity
Spumavirus/ISOLATION & PURIF/*PHYSIOLOGY/PATHOGENICITY Support,
Non-U.S. Gov't *Virus Replication JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).