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M9620444.TXT
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1996-02-26
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Document 0444
DOCN M9620444
TI [CMV and VZV encephalitis in AIDS]
DT 9602
AU Hassine D; Gray F; Chekroun R; De Truchis P; Schouman-Claeys E; Vallee
C; Service de Radiologie, Hopital Raymond Poincare, Garches.
SO J Neuroradiol. 1995 Sep;22(3):184-92. Unique Identifier : AIDSLINE
MED/96043314
AB MATERIAL AND METHODS: Eighty patients were followed up prospectively.
Histological correlation was obtained in 25 cases. All MRI examinations
were performed on at 0.5 Tesla in T1-weighted sequences with and without
gadolinium injection, and in axial or frontal T2-weighted spin echo
sequences. Histological confirmation was obtained 30 days on average
after the last MRI examination. Immunohistochemical stainings were
performed in search of CMV, VZV, toxoplasma, HIV antigen and lymphoma.
RESULTS: CMV meningoencephalitis was found in 6 cases. In 3 of these it
was manifested by atrophy, either isolated or associated with high
signal intensity punctiform areas. Histology detected cortical or
subcortical microglial nodules. In 2 cases MRI displayed abnormalities
of subependymal nodular signals without enhancement, associated with
punctiform abnormalities of subcortical signals. Histology showed
subependymal foci of necrosis and abnormalities of white matter. In one
case, MRI showed a ventriculitis confirmed by histology. VZV
meningoencephalitis was diagnosed in 2 cases. MRI displayed abnormal
basal ganglia related to meningitis (n = 1). All abnormalities were
confirmed at histology. CONCLUSION: Some images (ventriculitis,
infarction in basal ganglia, abnormal subependymal signal) would suggest
VZV and CMV encephalitis. Other images (abnormalities of punctiform
signals or atrophy) are not specific.
DE Atrophy AIDS-Related Opportunistic Infections/*DIAGNOSIS/PATHOLOGY
Basal Ganglia Diseases/DIAGNOSIS/PATHOLOGY/VIROLOGY Cerebral
Ventricles/PATHOLOGY Contrast Media Cytomegalovirus
Infections/*DIAGNOSIS/PATHOLOGY Encephalitis,
Viral/*DIAGNOSIS/PATHOLOGY English Abstract Ependyma/PATHOLOGY
Follow-Up Studies Gadolinium/DIAGNOSTIC USE Herpes
Zoster/*DIAGNOSIS/PATHOLOGY Human Immunohistochemistry *Magnetic
Resonance Imaging Meningoencephalitis/DIAGNOSIS/PATHOLOGY/VIROLOGY
Microglia/PATHOLOGY Necrosis Prospective Studies JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).