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1996-02-26
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Document 0459
DOCN M9620459
TI Sporadic ALS/MND: a global neurodegeneration with retroviral
involvement?
DT 9602
AU Westarp ME; Ferrante P; Perron H; Bartmann P; Kornhuber HH; Department
of Neurology, University of Ulm, Germany.
SO J Neurol Sci. 1995 May;129 Suppl:145-7. Unique Identifier : AIDSLINE
MED/96059169
AB Sporadic amyotrophic lateral sclerosis may be an aetiologically
heterogenous disease. We confirmed elevated circulating IgG immune
complexes, and altered IgG seroreactivities against human retroviral
antigens (HIV-2 and HTLV immunoblots) in overlapping subgroups of
patients. Together with preliminary findings of a positive polymerase
chain reactivity for human T-lymphotropic virus (HTLV.tax/rex) in blood
leukocytes of 5 out of 14 sALS patients, we interpret this as evidence
for a retroviral involvement in this relentlessly progressive, often
asymmetrically spreading neurodegeneration. The possibility of a
secondary phenomenon seems unlikely, yet cannot be completely ruled out.
DE Adult Aged Amyotrophic Lateral Sclerosis/*PATHOLOGY/*VIROLOGY
Antigens, Viral/ANALYSIS Human HIV-1/IMMUNOLOGY HIV-2/IMMUNOLOGY
HTLV-I/IMMUNOLOGY IgG/ANALYSIS Immunoblotting Middle Age Motor
Neuron Disease/*PATHOLOGY/*VIROLOGY Nerve Degeneration/*PHYSIOLOGY
Retroviridae Infections/*PATHOLOGY/*VIROLOGY Slow Virus
Diseases/*PATHOLOGY/*VIROLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).