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1996-02-26
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Document 0491
DOCN M9620491
TI Incidence and predictors of human immunodeficiency virus type 1
seroconversion in patients attending sexually transmitted disease
clinics in India.
DT 9602
AU Mehendale SM; Rodrigues JJ; Brookmeyer RS; Gangakhedkar RR; Divekar AD;
Gokhale MR; Risbud AR; Paranjape RS; Shepherd ME; Rompalo AE; et al;
National AIDS Research Institute, B. J. Medical College, Pune,; India.
SO J Infect Dis. 1995 Dec;172(6):1486-91. Unique Identifier : AIDSLINE
MED/96083492
AB The first estimates of the seroincidence of human immunodeficiency virus
type 1 (HIV-1) and of the risk factors for seroconversion in a cohort of
high-risk patients attending sexually transmitted disease (STD) clinics
in India are reported. Between 1993 and 1995, 851 HIV-1-seronegative
persons were evaluated prospectively every 3 months for HIV infection
and biologic and behavioral characteristics. The overall incidence of
HIV-1 was 10.2/100 person-years (95% confidence interval, 7.9-13.1). The
incidence among commercial sex workers (CSWs) was 26.1/100 person-years,
compared with 8.4 among non-CSWs. Recurrent genital ulcer disease and
urethritis or cervicitis during the follow-up period were independently
associated with a 7- (P < .001) and 3-fold (P = .06) increased risk of
HIV-1 seroconversion, respectively. Because of the association of
recurrent ulcerative and nonulcerative STDs with HIV-1 seroconversion in
this setting, behavioral and biologic measures directed at the
prevention and control of STDs would be expected to greatly reduce the
transmission of HIV-1 infection in similar high-risk groups.
DE Adult Aged Female Human HIV Seropositivity/*EPIDEMIOLOGY
HIV-1/*IMMUNOLOGY Incidence India/EPIDEMIOLOGY Male Middle Age Risk
Factors Sexually Transmitted Diseases/COMPLICATIONS Support, U.S.
Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).