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M9620506.TXT
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1996-02-26
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Document 0506
DOCN M9620506
TI Differential effect of human immunodeficiency virus infection on the IgA
and IgG antibody responses to pneumococcal vaccine.
DT 9602
AU Mascart-Lemone F; Gerard M; Libin M; Crusiaux A; Franchioly P;
Lambrechts A; Goldman M; Clumeck N; Department of Immunology, Hopital
Erasme, Brussels, Belgium.
SO J Infect Dis. 1995 Nov;172(5):1253-60. Unique Identifier : AIDSLINE
MED/96036381
AB The IgA, IgM, and IgG antibody responses to pneumococcal polysaccharide
vaccine were analyzed in 35 asymptomatic or mildly symptomatic human
immunodeficiency virus (HIV)-infected patients stratified according to
their CD4 cell counts and in 12 healthy controls. Both the antibody
titers in serum and saliva and the numbers of circulating
antigen-specific antibody-producing cells (Elispot technique) were
measured. At the peak of the antibody responses, HIV-infected patients
mounted nearly normal IgG responses, while their IgM responses were
significantly depressed, regardless of their CD4 cell counts. The IgA
antibody response was decreased in patients with < 500 CD4 circulating
cells/mm3. Most IgG antibodies belonged to the IgG2 subclass, and most
IgA antibodies were dimeric IgA2 in both controls and patients.
Anti-capsular pneumococcal polysaccharide IgG titers decreased much more
rapidly in HIV-infected patients so that in all groups they were
significantly lower than in controls 9 months after vaccination.
DE Adult Antibodies, Bacterial/BIOSYNTHESIS/*BLOOD Antibody Formation
Bacterial Vaccines/*IMMUNOLOGY Comparative Study Enzyme-Linked
Immunosorbent Assay Female Human HIV Infections/BLOOD/*IMMUNOLOGY
HIV Seronegativity HIV Seropositivity/BLOOD/*IMMUNOLOGY
IgA/BIOSYNTHESIS/*BLOOD IgG/BIOSYNTHESIS/*BLOOD Immunization Male
Middle Age Polysaccharides, Bacterial/*IMMUNOLOGY Streptococcus
pneumoniae/*IMMUNOLOGY Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).