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1996-02-26
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Document 0579
DOCN M9620579
TI [Kaposi sarcoma in Caucasian women. Clinical, chemical laboratory and
endocrinologic studies in 8 women with HIV-associated or classical
Kaposi sarcoma]
DT 9602
AU Schofer H; Roder C; Zentrum der Dermatologie und Venerologie, Abteilung
II, J. W.; Goethe-Universitat, Frankfurt.
SO Hautarzt. 1995 Sep;46(9):632-7. Unique Identifier : AIDSLINE
MED/96042936
AB Classic and HIV-associated Kaposi's sarcoma (KS) are predominantly found
in male Caucasians. It is unclear why KS is so rare in women. At the
Department of Dermatology, University of Frankfurt, epidemic KS was
diagnosed in 299/751 (40%) male and 5/72 (18%) female HIV-infected
patients. To detect common parameters regarding immunodeficiency,
hormonal disturbances, abnormalities in clinical course, or sexual
practices, data of eight women with KS (five HIV+, three HIV-) were
compared. In HIV+ women KS is more aggressive than in HIV- women and
more aggressive than in HIV+ men. Early and frequent visceral
involvement and no preference for the lower extremities are found.
Compared to HIV- women with KS, HIV+ women are generally younger (mean
age 38 vs 71 years) and significantly immunodeficient (reduced absolute
CD4 cell count and CD4/CD8 ratio). All women with KS investigated for
sexual hormones (7/8) showed abnormalities: 7/7 had low oestrogens, 4/6
low LH and 3/5 low progesterone. Controls (n = 11, HIV+ without KS)
showed a clear trend for higher serum levels of sexual hormones, but the
difference was not significant. Although different reasons for low
levels of oestrogens (drug abuse, marasmus, menopause) must be
considered, the lack of oestrogens seems to be a common finding in HIV+
and HIV- women with KS. There was no correlation between sexual
practices (anal or oral-faecal contacts) and the manifestation or
aggressiveness of KS.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS/TRANSMISSION Adult Aged
Aged, 80 and over Case Report *Caucasoid Race CD4 Lymphocyte Count
CD4-CD8 Ratio English Abstract Female Human Male Middle Age Risk
Factors Sarcoma, Kaposi's/*DIAGNOSIS/ETIOLOGY Sex Factors Sex
Hormones/BLOOD Skin Neoplasms/*DIAGNOSIS/ETIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).