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1996-02-26
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Document 0613
DOCN M9620613
TI HIV-1 incidence and HIV-1 associated mortality in a cohort of urban
factory workers in Tanzania.
DT 9602
AU Borgdorff MW; Barongo LR; Klokke AH; Newell JN; Senkoro KP; Velema JP;
Gabone RM; National Institute for Medical Research, Mwanza, Tanzania.
SO Genitourin Med. 1995 Aug;71(4):212-5. Unique Identifier : AIDSLINE
MED/96046496
AB OBJECTIVE--To determine HIV-1 incidence and HIV-1 associated mortality
in a prospective cohort study. To determine whether the cohort is
suitable for studies aiming to determine the impact of interventions on
HIV-1 incidence. METHODS--The study population was a cohort of 1772
urban factory workers (1478 men and 294 women) in northwest Tanzania.
The study took place from October 1991 to September 1993. Outcome
measures were HIV-1 seroconversion and death. RESULTS--HIV-1 incidence
was 1.2 (95% CI 0.7-2.0) per 100 person-years (pyr). Crude annual
mortality was 4.9 per 100 pyr in those with and 0.3 in those without
HIV-1 infection, giving an age and sex adjusted mortality ratio of 12.9
(95% CI 5.4-30.7). Of all deaths, 62% were attributable to HIV-1
infection. CONCLUSION--HIV-1 infection was a major public health
problem, being the major cause of death in this adult population. At an
HIV-1 incidence of 1.2 per 100 pyr, a large cohort size would be
required to evaluate the impact of interventions on HIV-1 incidence.
DE Adolescence Adult Aged Cohort Studies Female Human HIV
Infections/EPIDEMIOLOGY/*MORTALITY *HIV-1 Incidence Male Middle Age
Prevalence Random Allocation Risk Factors Support, Non-U.S. Gov't
Survival Rate Tanzania/EPIDEMIOLOGY Urban Health JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).