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1996-02-26
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Document 0631
DOCN M9620631
TI Drug-resistant tuberculosis in the 1990s [see comments]
DT 9602
AU Yew WW; Chau CH; Tuberculosis & Chest Unit, Grantham Hospital, Aberdeen,
Hong; Kong.
SO Eur Respir J. 1995 Jul;8(7):1184-92. Unique Identifier : AIDSLINE
MED/96016596
CM Comment in: Eur Respir J 1995 Jul;8(7):1073-5
AB There has been an upsurge of tuberculosis in many parts of the world in
the past decade. The high rates of drug-resistant tuberculosis currently
reported in many countries are alarming. The most catastrophic
phenomenon is the emergence of multidrug-resistant strains of
Mycobacterium tuberculosis. These organisms have caused epidemic
outbreaks in nosocomial and health-care settings in the USA and some
European countries. In addition to immigration, poverty, alcoholism and
intravenous substance abuse, human immunodeficiency virus (HIV)
infection has also had a significant impact on the prevalence of drug
resistance, since amongst these patient groups a common factor giving
rise to drug resistance is noncompliance. Rapid drug susceptibility
tests are needed, and effective chemotherapy regimens with newly
developed drugs in combination with traditional second-line
antituberculosis agents for established multidrug-resistant tuberculosis
are urgently being sought. There is also a quest for other novel
modalities of therapy. Measures should be actively adopted to prevent
the development of drug resistance. Well formulated short-course
chemotherapy as initial treatment and ensurance of compliance are the
most important components. The organization of a national tuberculosis
control programme with a sound and adequately functioning infrastructure
remains the most effective strategy to combat the resurgence of
tuberculosis and to curtail drug resistance.
DE Antitubercular Agents/*THERAPEUTIC USE AIDS-Related Opportunistic
Infections/EPIDEMIOLOGY/MICROBIOLOGY Drug Resistance, Microbial Drug
Therapy, Combination Human Microbial Sensitivity Tests Mycobacterium
tuberculosis/DRUG EFFECTS Patient Compliance Prevalence Tuberculosis,
Multidrug-Resistant/DRUG THERAPY/*EPIDEMIOLOGY/ THERAPY Tuberculosis,
Pulmonary/DRUG THERAPY/*EPIDEMIOLOGY/THERAPY JOURNAL ARTICLE REVIEW
REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).