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M9620656.TXT
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1996-02-26
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Document 0656
DOCN M9620656
TI Catheter-related cutaneous aspergillosis complicated by fungemia and
fatal pulmonary infection in an HIV-positive patient with acute
lymphocytic leukemia.
DT 9602
AU Girmenia C; Gastaldi R; Martino P; Department of Human Biopathology,
University La Sapienza, Rome,; Italy.
SO Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):524-6. Unique Identifier
: AIDSLINE MED/96082797
AB A case of intravenous catheter-related cutaneous aspergillosis and
Aspergillus fumigatus fungemia in an HIV-positive patient with
Burkitt-cell acute lymphocytic leukemia is reported. The patient
developed pulmonary aspergillosis with a rapidly fatal outcome despite
recovery from neutropenia and improvement of the underlying malignancy.
The unusual severity and rapid spread of the infection, despite normal
neutrophil count and prompt antifungal therapy, suggest that HIV-related
immunocompromise might play a role in the impairment of host defences
against Aspergillus infection. Thus catheter-related cutaneous
aspergillosis could lead to a severe deep-seated infection in
HIV-positive patients.
DE Adult Antifungal Agents/THERAPEUTIC USE
Aspergillosis/*COMPLICATIONS/DRUG THERAPY/ETIOLOGY Case Report
Catheterization, Central Venous/ADVERSE EFFECTS
Dermatomycoses/*COMPLICATIONS/DRUG THERAPY/ETIOLOGY Disease Progression
Fatal Outcome Female Fungemia/*COMPLICATIONS/DRUG THERAPY/ETIOLOGY
Human Leukemia, Lymphocytic, Acute/*COMPLICATIONS Opportunistic
Infections/*COMPLICATIONS/DRUG THERAPY Pneumonia/*COMPLICATIONS/DRUG
THERAPY Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).