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1996-02-26
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Document 0665
DOCN M9620665
TI [Anxious-depressive state and cognitive deficit in HIV infection]
DT 9602
AU Silvestre D; Linard F; Desi M; Seibel N; Korezlioglu J; Pequart C;
Saimot AG; U158 INSERM, Hopital Necker-Enfants Malades, Paris.
SO Encephale. 1995 Jul-Aug;21(4):285-8. Unique Identifier : AIDSLINE
MED/96004061
AB This study tries to demonstrate the importance of using follow-up trials
and taking anxio-depressive status into account while interpreting
cognitive impairment in HIV-infected subjects. Subjects included were:
18 HIV carriers, mostly homosexual, belonging to CDC groups II (4), III
or IVC2 (7) and IV (7), selected within a cohort of 63, as having been
assessed 3 times, with no focal or identified brain disease at entry.
Our methods were: 1) psychiatric interview based on DSM III-R criteria,
clinical scales (Spielberger's STAXI and the MADRS) and cognitive
questionnaires; 2) neuropsychological evaluation including 16 subtests
screening attention, memory, visuo-spatial function, motor dexterity,
psychomotor speed, and language; 3) repeated assessment within a period
ranging from 6 to 21 months. Results: At entry, cognitive status was
impaired for 14 subjects (2 II, 5 III or IVC2, 7 IV). Disorders had
disappeared for 7 subjects (2 II, 2 IVC2 and 3 IV) at following
assessments allowing us to conclude on a psychogenic origin. For 7
subjects, cognitive status had either remained constant (3 III and 2 II)
or had worsened within 7 to 17 months (2 IV), whereas psychiatric
symptoms had decreased, implying HIV encephalopathy. Follow-up trials
including 3 neuropsychological and psychiatric assessments and
neuroimagery, if necessary, were required to ascertain the causes of
cognitive impairment consequently attributed to anxio-depressive
symptoms or HIV encephalopathy in 14 subjects.
DE Adult Aged Anxiety Disorders/DIAGNOSIS/*PSYCHOLOGY AIDS Dementia
Complex/DIAGNOSIS/*PSYCHOLOGY Cohort Studies Depressive
Disorder/DIAGNOSIS/*PSYCHOLOGY English Abstract Female Homosexuality,
Male/PSYCHOLOGY Human HIV Seropositivity/DIAGNOSIS/*PSYCHOLOGY Male
Middle Age Neuropsychological Tests Personality Inventory Sick Role
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).