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1996-02-26
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Document 0690
DOCN M9620690
TI Cytotoxic T lymphocytes and HIV-1 related neurologic disorders.
DT 9602
AU Kalams SA; Walker BD; Infectious Disease Unit, Harvard Medical School,
Boston, MA, USA.
SO Curr Top Microbiol Immunol. 1995;202:79-88. Unique Identifier : AIDSLINE
MED/96004229
AB In summary, one can conclude that infected persons exhibit an extremely
vigorous, virus-specific CTL response, and in at least some individuals
this response is broadly directed at multiple epitopes. These cells are
present at the time or initial control of viremia and can also be
detected after more than a decade of asymptomatic infection. These cells
can also be found in the central nervous system in persons with ADC, and
one can envision pathways in which the inflammatory cytokines released
by these cells upon activation could contribute to the neurologic
sequelae of infection. However, the precise role of these cells as a
protective host defense and the possible contribution of these cells, or
products released by these cells, to tissue damage at sites such as the
lung and brain remain to be determined. Further delineation of the role
played by CTLs in the pathogenesis of disease should be extremely useful
in helping to understand the disease itself and to guide intervention
strategies.
DE AIDS Dementia Complex/*COMPLICATIONS/IMMUNOLOGY Cytokines/PHYSIOLOGY
Cytotoxicity, Immunologic Human HIV
Infections/*COMPLICATIONS/IMMUNOLOGY *HIV-1/IMMUNOLOGY Peripheral
Nervous System Diseases/*ETIOLOGY/IMMUNOLOGY/VIROLOGY T-Lymphocyte
Subsets/IMMUNOLOGY T-Lymphocytes, Cytotoxic/*IMMUNOLOGY JOURNAL
ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).