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1996-02-26
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Document 0734
DOCN M9620734
TI Components of biological variation in plasma haptoglobin: relationships
to plasma fibrinogen and immune variables, including interleukin-6 and
its receptor.
DT 9602
AU Maes M; Cooreman W; Delanghe J; Scharpe S; Wauters A; Neels H; D'Hondt
P; Peeters D; Cosyns P; Ranjan R; et al; Department of Psychiatry,
University Hospitals of Cleveland,; Ohio, USA.
SO Clin Chim Acta. 1995 Jul 31;239(1):23-35. Unique Identifier : AIDSLINE
MED/96051324
AB We investigated the components of biological variation, including
seasonality, in plasma haptoglobin (Hp) levels and the relationships
between plasma Hp and interleukin-6 (IL-6), soluble IL-6 receptor
(sIL-6), sIL-2R, fibrinogen (Fb) and absolute number of peripheral blood
mononuclear cells, such as leukocytes, neutrophils, monocytes,
lymphocytes, CD4+, CD8+, CD25+ T cells and CD20+ B cells. Monthly blood
samples were taken from 26 normal volunteers during one calendar year.
The estimated inter- and intra-individual C.V. values for plasma Hp were
27.9% and 20.0%, respectively; the index of individuality was 0.72. No
significant seasonal rhythms could be detected in plasma Hp levels. The
yearly mean values in plasma Hp were significantly and positively
related to those in plasma Fb, absolute number of leukocytes,
neutrophils, CD4+ T cells and the CD4+/CD8+ T cell ratio. 49.0% of the
variance in the yearly mean values of plasma Hp could be explained by
variances in serum IL-6 and number of CD4+ (positively related) and CD8+
(negatively related) T cells. There were significant and positive time
relationships between plasma Hp, on the one hand, and plasma Fb, sIL-6R,
sIL-2R and number of leukocytes, neutrophils and monocytes, on the
other. A smaller part of the within-subject variability in plasma Hp
(i.e. 6.0%) could be explained by serum sIL-6R and sIL-2R. It is
concluded that there are (1) important between-subject differences in
the homeostatic setpoints of plasma Hp, which are related to those in
plasma Fb and in immune status and (2) significant within-subject, time
relationships between plasma Hp and indicators of immune activation and
plasma Fb.
DE Adult Aged Antigens, CD/*METABOLISM Comparative Study CD4-CD8 Ratio
Female Fibrinogen/*METABOLISM Haptoglobins/*METABOLISM Human
*Immunity Interleukin-6/*METABOLISM Leukocyte Count Leukocytes,
Mononuclear Male Middle Age Monocytes Neutrophils Receptors,
Interleukin/*METABOLISM Seasons Support, Non-U.S. Gov't JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).