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- Document 0734
- DOCN M9620734
- TI Components of biological variation in plasma haptoglobin: relationships
- to plasma fibrinogen and immune variables, including interleukin-6 and
- its receptor.
- DT 9602
- AU Maes M; Cooreman W; Delanghe J; Scharpe S; Wauters A; Neels H; D'Hondt
- P; Peeters D; Cosyns P; Ranjan R; et al; Department of Psychiatry,
- University Hospitals of Cleveland,; Ohio, USA.
- SO Clin Chim Acta. 1995 Jul 31;239(1):23-35. Unique Identifier : AIDSLINE
- MED/96051324
- AB We investigated the components of biological variation, including
- seasonality, in plasma haptoglobin (Hp) levels and the relationships
- between plasma Hp and interleukin-6 (IL-6), soluble IL-6 receptor
- (sIL-6), sIL-2R, fibrinogen (Fb) and absolute number of peripheral blood
- mononuclear cells, such as leukocytes, neutrophils, monocytes,
- lymphocytes, CD4+, CD8+, CD25+ T cells and CD20+ B cells. Monthly blood
- samples were taken from 26 normal volunteers during one calendar year.
- The estimated inter- and intra-individual C.V. values for plasma Hp were
- 27.9% and 20.0%, respectively; the index of individuality was 0.72. No
- significant seasonal rhythms could be detected in plasma Hp levels. The
- yearly mean values in plasma Hp were significantly and positively
- related to those in plasma Fb, absolute number of leukocytes,
- neutrophils, CD4+ T cells and the CD4+/CD8+ T cell ratio. 49.0% of the
- variance in the yearly mean values of plasma Hp could be explained by
- variances in serum IL-6 and number of CD4+ (positively related) and CD8+
- (negatively related) T cells. There were significant and positive time
- relationships between plasma Hp, on the one hand, and plasma Fb, sIL-6R,
- sIL-2R and number of leukocytes, neutrophils and monocytes, on the
- other. A smaller part of the within-subject variability in plasma Hp
- (i.e. 6.0%) could be explained by serum sIL-6R and sIL-2R. It is
- concluded that there are (1) important between-subject differences in
- the homeostatic setpoints of plasma Hp, which are related to those in
- plasma Fb and in immune status and (2) significant within-subject, time
- relationships between plasma Hp and indicators of immune activation and
- plasma Fb.
- DE Adult Aged Antigens, CD/*METABOLISM Comparative Study CD4-CD8 Ratio
- Female Fibrinogen/*METABOLISM Haptoglobins/*METABOLISM Human
- *Immunity Interleukin-6/*METABOLISM Leukocyte Count Leukocytes,
- Mononuclear Male Middle Age Monocytes Neutrophils Receptors,
- Interleukin/*METABOLISM Seasons Support, Non-U.S. Gov't JOURNAL
- ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-