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M9620736.TXT
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1996-02-26
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Document 0736
DOCN M9620736
TI The inhibitory effect of the crude extract from a seaweed of Dygenea
simplex C. Agardh on the in vitro cytopathic activity of HIV-1 and it's
antigen production.
DT 9602
AU Sekine H; Ohonuki N; Sadamasu K; Monma K; Kudoh Y; Nakamura H; Okada Y;
Okuyama T; Department of Microbiology, Tokyo Metropolitan Research;
Laboratory of Public Health, Japan.
SO Chem Pharm Bull (Tokyo). 1995 Sep;43(9):1580-4. Unique Identifier :
AIDSLINE MED/96003369
AB The crude water extract (NS-1) from a seaweed (Digenea simplex C. Agardh
Rhodomelaceae) exhibited anti-human immunodeficiency virus (HIV)-1
activity in vitro. The inhibitory effect of the extract on the
cytopathic activity of HIV-1 and it's antigen production was examined
using a microplate method, immunofluorescent assay, and an HIV antigen
detection kit (Abbott). NS-1 inhibited both the cytopathic effect of
HIV-1 to MT-4 cells and the giant cell formation of Molt-4 cells
infected with HIV-1.
DE Antiviral Agents/CHEMISTRY/*PHARMACOLOGY Cell Line Chemistry, Physical
Cytopathogenic Effect, Viral/*DRUG EFFECTS Fluorescent Antibody
Technique, Indirect Human HIV Antigens/*BIOSYNTHESIS HIV-1/*DRUG
EFFECTS/IMMUNOLOGY Molecular Weight Plant
Extracts/CHEMISTRY/*PHARMACOLOGY T-Lymphocytes/IMMUNOLOGY/VIROLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).