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M9620846.TXT
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1996-02-26
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Document 0846
DOCN M9620846
TI Comparison of the declines in CD4 counts in HIV-1-seropositive female
sex workers and women from the general population in Nairobi, Kenya.
DT 9602
AU Bwayo JJ; Nagelkerke NJ; Moses S; Embree J; Ngugi EN; Mwatha A; Kimani
J; Anzala A; Choudhri S; Achola JO; et al; Department of Medical
Microbiology, University of Nairobi, Kenya.
SO J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):457-61.
Unique Identifier : AIDSLINE MED/96074279
AB Studies from Kenya have reported rapid clinical disease progression
among HIV-infected professional sex workers. The reasons for this rapid
decline are unknown. To better understand factors influencing the course
of disease, HIV-1 disease progression was explored in terms of declines
in CD4 counts. Two samples from Nairobi, Kenya, were studied, one from a
cohort of female sex workers and another, as a comparison group, from
mothers enrolled in an HIV-1 vertical-transmission study. A Markov model
was used to analyze transitions between HIV-1 disease stages as defined
by CD4 counts. It appears that sex workers experience a rapid decline in
CD4 counts, consistent with earlier findings of rapid clinical disease
progression among individuals in this group. The rate of decline in CD4
counts among the mothers appears to be lower. It is speculated that
either intensive exposure to sexually transmitted pathogens or infection
with several strains of HIV-1 may account for the rapid disease
progression among female sex workers.
DE Adult Cohort Studies Comparative Study CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes/*IMMUNOLOGY Disease Progression Disease
Transmission, Vertical Female Human HIV Infections/TRANSMISSION HIV
Seropositivity/*IMMUNOLOGY/TRANSMISSION *HIV-1 Kenya Markov Chains
*Prostitution Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).