home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Collection of Education
/
collectionofeducationcarat1997.iso
/
HEALTH
/
MED9602.ZIP
/
M9620857.TXT
< prev
next >
Wrap
Text File
|
1996-02-26
|
3KB
|
44 lines
Document 0857
DOCN M9620857
TI HIV-associated renal disease in London hospitals.
DT 9602
AU Connolly JO; Weston CE; Hendry BM; Department of Medicine, King's
College Hospital School of; Medicine and Dentistry, London, UK.
SO QJM. 1995 Sep;88(9):627-34. Unique Identifier : AIDSLINE MED/96030958
AB We report experience from London hospitals which further illustrates the
heterogeneous nature of HIV-associated nephropathy (HIVAN). Nineteen
HIV-positive patients underwent renal biopsy from 1992 to 1994. Fourteen
were male, five female. Eleven were Afro-Caribbean, 7 Caucasian and 1
Asian. Eleven patients had classical HIVAN with proteinuria, rapidly
progressive renal failure and features of focal and segmental
glomerulosclerosis (FSGS) on renal biopsy, and three of these had
associated tubulo-interstitial nephritis (TIN). One further patient had
TIN and tubular changes suggestive of HIVAN but no glomeruli were
present in the biopsy. Other biopsy findings were of focal proliferative
glomerulonephritis and TIN (1 patient), pauci-immune crescentic
glomerulonephritis and TIN (1 patient), membranous nephropathy (1
patient), membranoproliferative nephropathy (1 patient) and haemolytic
uraemic syndrome (2 patients). Of 11 patients with FSGS, seven died with
median survival of 8 months (range 23 days-46 months) and five are still
alive after median follow-up of 18 months (range 10-22 months). Of
patients with glomerular disease other than FSGS, five died, with median
survival of 3 months (range 1-27 months) and two have survived (10 and
27 months, respectively). Thirteen patients had renal failure, 10 of
whom had FSGS. In 10 cases renal failure was acute and in two was the
presenting feature of HIV infection. Thirteen patients underwent renal
replacement therapy. Four received haemodialysis, and all died within
one month. Nine patients received CAPD. Two were able to discontinue
dialysis. Of the remaining seven, five died with median survival of 8
months (range 1.3-40 months) and two are alive 1 and 10 months after
beginning dialysis.(ABSTRACT TRUNCATED AT 250 WORDS)
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult
AIDS-Associated Nephropathy/*PATHOLOGY Female Follow-Up Studies
Glomerulonephritis/PATHOLOGY/VIROLOGY Hemodialysis Human Kidney
Failure/PATHOLOGY/THERAPY/VIROLOGY Male Middle Age Nephritis,
Interstitial/PATHOLOGY/VIROLOGY Prognosis Treatment Outcome JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).