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- Document 0857
- DOCN M9620857
- TI HIV-associated renal disease in London hospitals.
- DT 9602
- AU Connolly JO; Weston CE; Hendry BM; Department of Medicine, King's
- College Hospital School of; Medicine and Dentistry, London, UK.
- SO QJM. 1995 Sep;88(9):627-34. Unique Identifier : AIDSLINE MED/96030958
- AB We report experience from London hospitals which further illustrates the
- heterogeneous nature of HIV-associated nephropathy (HIVAN). Nineteen
- HIV-positive patients underwent renal biopsy from 1992 to 1994. Fourteen
- were male, five female. Eleven were Afro-Caribbean, 7 Caucasian and 1
- Asian. Eleven patients had classical HIVAN with proteinuria, rapidly
- progressive renal failure and features of focal and segmental
- glomerulosclerosis (FSGS) on renal biopsy, and three of these had
- associated tubulo-interstitial nephritis (TIN). One further patient had
- TIN and tubular changes suggestive of HIVAN but no glomeruli were
- present in the biopsy. Other biopsy findings were of focal proliferative
- glomerulonephritis and TIN (1 patient), pauci-immune crescentic
- glomerulonephritis and TIN (1 patient), membranous nephropathy (1
- patient), membranoproliferative nephropathy (1 patient) and haemolytic
- uraemic syndrome (2 patients). Of 11 patients with FSGS, seven died with
- median survival of 8 months (range 23 days-46 months) and five are still
- alive after median follow-up of 18 months (range 10-22 months). Of
- patients with glomerular disease other than FSGS, five died, with median
- survival of 3 months (range 1-27 months) and two have survived (10 and
- 27 months, respectively). Thirteen patients had renal failure, 10 of
- whom had FSGS. In 10 cases renal failure was acute and in two was the
- presenting feature of HIV infection. Thirteen patients underwent renal
- replacement therapy. Four received haemodialysis, and all died within
- one month. Nine patients received CAPD. Two were able to discontinue
- dialysis. Of the remaining seven, five died with median survival of 8
- months (range 1.3-40 months) and two are alive 1 and 10 months after
- beginning dialysis.(ABSTRACT TRUNCATED AT 250 WORDS)
- DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult
- AIDS-Associated Nephropathy/*PATHOLOGY Female Follow-Up Studies
- Glomerulonephritis/PATHOLOGY/VIROLOGY Hemodialysis Human Kidney
- Failure/PATHOLOGY/THERAPY/VIROLOGY Male Middle Age Nephritis,
- Interstitial/PATHOLOGY/VIROLOGY Prognosis Treatment Outcome JOURNAL
- ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-