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1996-02-26
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Document 0865
DOCN M9620865
TI [African histoplasmosis due to Histoplasma capsulatum var. duboisii:
relationship with AIDS in recent Congolese cases]
DT 9602
AU Chandenier J; Goma D; Moyen G; Samba-Lefebvre MC; Nzingoula S; Obengui;
Mbitsi A; Nkiwabonga L; Ngaporo AI; Service de parasitologie-mycologie,
CHU de Brazzaville, Congo.
SO Sante. 1995 Jul-Aug;5(4):227-34. Unique Identifier : AIDSLINE
MED/96016648
AB Six new cases are described for African histoplasmosis, Histoplasma
capsulatum var. duboisii, from Congo. The first was an HIV sero-negative
child who has been monitored for the last three years. While under
treatment with ketoconazole, amphotericin B, and finally itraconazole,
the development of the infection was accompanied by purulent lesions,
mainly cutaneous, but also superficial and deep lymphadenopathies. As a
last option, itraconazole gave very satisfactory results both during the
acute phase and during long-term treatment. However, eight months after
treatment had ceased, there was a relapse and the long-term treatment
had to be restarted. The other cases concerned HIV sero-positive
patients with disseminated infections that had all been mistaken for
tuberculosis. After diagnosis of the infection in two cases, the
following two years of treatment could not prevent death. A fourth case,
diagnosed in December 1994, is currently undergoing treatment. The fifth
subject was lost after diagnosis during follow-up, but inquires made
after the discovery of the patient's death strongly indicated acquired
immunodeficiency as the cause. The last of these six cases, determined
as HIV sero-negative, showed large bony lesions of the spinal column
associated with a sore on the thorax. Thus, in a short period of time,
three or four cases of African histoplasmosis occurred which were
associated with HIV infection. Only seven identical observations have
previously been reported in the literature. Therefore, we believe that
this mycosis should now be included in the criteria for the diagnosis
and definition of AIDS in the tropics.
DE Adult AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY/
*MICROBIOLOGY Case Report Congo English Abstract Fatal Outcome
Female Histoplasma/*CLASSIFICATION Histoplasmosis/DIAGNOSIS/DRUG
THERAPY/*MICROBIOLOGY Human Male Middle Age Recurrence JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).