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1996-02-26
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Document 0948
DOCN M9620948
TI Factors associated with extrapulmonary tuberculosis as an AIDS-defining
disease in Europe. The Coordinators of AIDS surveillance in Austria,
Belgium, France, Germany, Italy, Portugal, Switzerland, United Kingdom
and the city of Amsterdam.
DT 9602
AU Schwoebel V; Delmas MC; Ancelle-Park RA; Brunet JB; European Centre for
the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.
SO Tuber Lung Dis. 1995 Aug;76(4):281-5. Unique Identifier : AIDSLINE
MED/96048189
AB SETTING: Western Europe: 8 countries and the city of Amsterdam.
OBJECTIVE: To identify factors associated with extrapulmonary
tuberculosis (EPTB) at AIDS diagnosis among adult AIDS patients. DESIGN:
The proportion of AIDS case diagnosed between January 1988 and June 1992
with EPTB was analysed by age, gender, year of diagnosis, country and
HIV transmission category. Multiple logistic regression was performed
separately for patients infected through heterosexual contact who were
likely to originate from Africa or the Caribbean (heterosexual subgroup
1), and for other patients. RESULTS: The overall proportion with EPTB
was 4.6% and remained stable between 1988 and 1992. It differed
significantly by country (from 2.4% in the United Kingdom to 24.7% in
Portugal) and by transmission category (2.7% among homo/bisexuals, 5.8%
among injecting drug users, 13.6% among heterosexual subgroup 1). In
multivariate analysis, the risk of EPTB was independently associated
with younger age and male gender. Among patients other than from
heterosexual subgroup 1, country and transmission category were also
independent predictors of EPTB at AIDS diagnosis. CONCLUSION: The risk
of presenting EPTB as an AIDS-defining disease is not homogeneous within
Europe. Results suggest an increased risk of tuberculosis in specific
groups of HIV-infected persons (persons originating from sub-Saharan
Africa, injecting drug users) and a potential role of recent
Mycobacterium tuberculosis infection among younger patients.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adolescence Adult
Age Factors Aged AIDS-Related Opportunistic
Infections/*COMPLICATIONS/EPIDEMIOLOGY Europe/EPIDEMIOLOGY Female
Human HIV Infections/TRANSMISSION Male Middle Age Risk Factors Sex
Factors Support, Non-U.S. Gov't
Tuberculosis/*COMPLICATIONS/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).