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1996-02-26
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Document 1063
DOCN M9621063
TI The incidence of complications after caesarean section in 156
HIV-positive women.
DT 9602
AU Semprini AE; Castagna C; Ravizza M; Fiore S; Savasi V; Muggiasca ML;
Grossi E; Guerra B; Tibaldi C; Scaravelli G; et al; Department of
Obstetrics and Gynaecology, San Paolo Biomedical; Institute, Milan,
Italy.
SO AIDS. 1995 Aug;9(8):913-7. Unique Identifier : AIDSLINE MED/96014966
AB OBJECTIVE: To investigate the risks of post-operative complications in
HIV-positive mothers who undergo a caesarean section (CS) because the
delivery cannot be safely accomplished by the vaginal route or to
protect the infant from viral infection. DESIGN: In a multicentre study,
we reviewed the incidence and type of post-operative complications in
156 HIV-positive women who underwent a CS. These results were compared
with those observed in an equal number of HIV-uninfected women who
matched for the indication requiring a caesarean delivery, the stage of
labour, the integrity or rupture of membranes, and the use of antibiotic
prophylaxis. SETTING: Seven teaching hospitals providing obstetrical
care for mothers infected with HIV. RESULTS: We found that six
HIV-infected mothers suffered a major complication (two cases of
pneumonia, one pleural effusion, two severe anaemia and one sepsis)
compared with only one HIV-negative woman who required blood transfusion
after surgery. Minor complications like post-operative fever,
endometritis, wound and urinary tract infections were significantly more
frequent in HIV-positive women than controls. Multivariate analysis
revealed that in HIV-infected women the only factor associated with a
significant increase in the rate of complications was a CD4 lymphocyte
count < 200 x 10(6)/l. CONCLUSIONS: The results of our study indicate
that HIV-positive mothers are at an increased risk of post-operative
complications when delivered by CS. The risk of post-operative
complications is higher in HIV-infected women who are severely
immunodepressed.
DE Case-Control Studies Cesarean Section/*ADVERSE EFFECTS CD4 Lymphocyte
Count Female Human HIV Infections/BLOOD/*COMPLICATIONS/IMMUNOLOGY
Infant, Newborn Postoperative Complications/*ETIOLOGY Pregnancy
Pregnancy Complications, Infectious/BLOOD/*ETIOLOGY/IMMUNOLOGY Risk
Factors Support, Non-U.S. Gov't JOURNAL ARTICLE MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).