home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Collection of Education
/
collectionofeducationcarat1997.iso
/
HEALTH
/
MED9602.ZIP
/
M9621081.TXT
< prev
next >
Wrap
Text File
|
1996-02-26
|
2KB
|
35 lines
Document 1081
DOCN M9621081
TI Serum reactivity against an immunoregulatory sequence of HIV p24 in
HIV-1-infected subjects.
DT 9602
AU Cordiali Fei P; Solmone M; Prignano G; Pugliese O; Viora M; Luzzati A;
Ameglio F; Laboratory of Clinical Pathology, Istituto San Gallicano,
Rome,; Italy.
SO Viral Immunol. 1994;7(4):199-203. Unique Identifier : AIDSLINE
MED/96100714
AB The aim of this study was to assess the antibody reactivity in
HIV-infected subjects against an HIV-1 p24 sequence, p226 (aa226-237),
including a seven amino acid epitope showing immunosuppressive activity
in vitro and to evaluate the relationship between anti-peptide antibody
levels and disease progression. Sera of HIV-infected subjects, at
different stages of disease, were compared to control sera in a
retrospective evaluation. Recombinant HIV-1 p24 and p24- and
control-peptides were used in an enzyme immunoassay as targets for
antibodies present in the sera. Antibodies directed against the whole
p24 protein and its peptides were found in all the sera studied but at
different levels. The anti-p226 reactivity was not significantly
different at different clinical stages. Nevertheless, it was inversely
correlated to the reactivity directed against the whole protein, that
was lower in subjects characterized by low CD4 cell numbers.
DE Amino Acid Sequence CD4 Lymphocyte Count Human HIV
Antibodies/BIOSYNTHESIS/*BLOOD HIV Core Protein
p24/*IMMUNOLOGY/PHARMACOLOGY HIV Infections/*BLOOD/IMMUNOLOGY
HIV-1/IMMUNOLOGY Immunosuppressive Agents/*PHARMACOLOGY Lymphocyte
Transformation Molecular Sequence Data Support, Non-U.S. Gov't
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).