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M9651032.TXT
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1996-03-30
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Document 1032
DOCN M9651032
TI Prevention of recurrent herpes simplex virus (HSV) infections in
HIV-infected persons.
DT 9505
AU Chang E; Absar N; Beall G; Harbor-UCLA Medical Center, Torrance, USA.
SO AIDS Patient Care. 1995 Oct;9(5):252-5. Unique Identifier : AIDSLINE
AIDS/96156728
AB The purpose of this study was to determine the frequency of HSV
infections and recurrences among HIV-infected patients and to examine
different regimens for suppression of HSV recurrence. A randomized
retrospective chart review of HIV-infected patients at a public hospital
in Los Angeles County was conducted. We reviewed 224 patients' charts;
26 percent had AIDS based on the 1987 CDC definition. HSV infection was
documented as a clinical event in 51 records (23 percent). Patients with
an AIDS diagnosis had a greater incidence (53 percent) of HSV infections
than did those with a diagnosis of symptomatic or asymptomatic HIV
infection (p < 0.001, Fisher's exact test). Recurrences of HSV occurred
in 26 (51 percent) of the 51 HSV-infected persons during a period of
1042 patient months. Eighteen patients who had received acyclovir
suppression at 600 mg/day had three HSV recurrences in 382 patient
months, whereas 14 who received 400 mg/day had eight recurrences in 282
patient months (p = 0.02). HSV infections occur in 23 percent of
HIV-infected patients, increasing to 53 percent in AIDS patients.
Acyclovir suppression prevents recurrent HSV, and a dosage of 600 mg/day
is more effective than 400 mg/day.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS Acyclovir/*THERAPEUTIC
USE Adult Antiviral Agents/*THERAPEUTIC USE Decision Making Female
Herpes Simplex/COMPLICATIONS/DRUG THERAPY/EPIDEMIOLOGY/ *PREVENTION &
CONTROL Human HIV Infections/*COMPLICATIONS Male Middle Age Random
Allocation Recurrence Retrospective Studies Risk Factors United
States/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).