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- Document 1090
- DOCN M9651090
- TI Mother-to-child transmission of human immunodeficiency virus type 1 and
- type 2 and dual infection: a cohort study in Banfora, Burkina Faso.
- DT 9505
- AU Prazuck T; Yameogo JM; Heylinck B; Ouedraogo LT; Rochereau A;
- Guiard-Schmid JB; Lechuga P; Agranat P; Cot M; Malkin JE; et al; Groupe
- d'Etudes Epidemiologiques et Prophylactiques (GEEP),; Centre
- Hospitalier, France.
- SO Pediatr Infect Dis J. 1995 Nov;14(11):940-7. Unique Identifier :
- AIDSLINE MED/96147525
- AB A prospective cohort study on the mother-to-child transmission of human
- immunodeficiency virus type 1 (HIV1), type 2 (HIV2) and dual positivity
- (HIV1 + HIV2) was carried out in Banfora, West Burkina Faso. The study
- samples consist of 117 newborns of HIV-seropositive women matched to 234
- newborns of HIV-seronegative women. Among cases, 91 were born of
- HIV1-seropositive mothers, 15 were born of HIV2-seropositive mothers and
- 11 were born of HIV1 and HIV2 dual-seropositive mothers and were
- included in an 18-month follow-up. Calculation of the mother-to-child
- transmission rate was according to the recommendations of the European
- Economic Community working group. The HIV1 mother-to-child transmission
- rate was estimated to be 27.8% (95% confidence interval (CI) 24.5 to
- 32.4) with one method and 25.5% (95% CI 13.5 to 37.5) with a second
- method. For HIV2, this rate was estimated to be 29.5% (95% CI 26.0 to
- 39.8) and was not statistically different from the HIV1 mother-to-child
- transmission rate. No case of transmission was observed in children born
- of dual seropositive mothers. Survival rate at month 18 was
- significantly lower for children born of HIV1 mothers: 83.7% (95% CI
- 78.2 to 92.2). Survival rates were similar between children born of
- HIV2-seropositive (86.7), dual HIV1 + 2-positive (100) and seronegative
- mothers (92.0%). Findings suggest a higher mother-to-child transmission
- rate of HIV2 in children born in Burkina Faso than in Europe and a low
- clinical expression of HIV2 in children.
- DE Adult Africa AIDS Serodiagnosis Cohort Studies *Disease
- Transmission, Vertical Female Follow-Up Studies Human HIV
- Infections/DIAGNOSIS/MORTALITY/*TRANSMISSION HIV Seroprevalence
- HIV-1/*ISOLATION & PURIF HIV-2/*ISOLATION & PURIF Incidence Infant
- Pregnancy Pregnancy Complications, Infectious/*VIROLOGY Prospective
- Studies Support, Non-U.S. Gov't Survival Rate JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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