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M9651090.TXT
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1996-03-30
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Document 1090
DOCN M9651090
TI Mother-to-child transmission of human immunodeficiency virus type 1 and
type 2 and dual infection: a cohort study in Banfora, Burkina Faso.
DT 9505
AU Prazuck T; Yameogo JM; Heylinck B; Ouedraogo LT; Rochereau A;
Guiard-Schmid JB; Lechuga P; Agranat P; Cot M; Malkin JE; et al; Groupe
d'Etudes Epidemiologiques et Prophylactiques (GEEP),; Centre
Hospitalier, France.
SO Pediatr Infect Dis J. 1995 Nov;14(11):940-7. Unique Identifier :
AIDSLINE MED/96147525
AB A prospective cohort study on the mother-to-child transmission of human
immunodeficiency virus type 1 (HIV1), type 2 (HIV2) and dual positivity
(HIV1 + HIV2) was carried out in Banfora, West Burkina Faso. The study
samples consist of 117 newborns of HIV-seropositive women matched to 234
newborns of HIV-seronegative women. Among cases, 91 were born of
HIV1-seropositive mothers, 15 were born of HIV2-seropositive mothers and
11 were born of HIV1 and HIV2 dual-seropositive mothers and were
included in an 18-month follow-up. Calculation of the mother-to-child
transmission rate was according to the recommendations of the European
Economic Community working group. The HIV1 mother-to-child transmission
rate was estimated to be 27.8% (95% confidence interval (CI) 24.5 to
32.4) with one method and 25.5% (95% CI 13.5 to 37.5) with a second
method. For HIV2, this rate was estimated to be 29.5% (95% CI 26.0 to
39.8) and was not statistically different from the HIV1 mother-to-child
transmission rate. No case of transmission was observed in children born
of dual seropositive mothers. Survival rate at month 18 was
significantly lower for children born of HIV1 mothers: 83.7% (95% CI
78.2 to 92.2). Survival rates were similar between children born of
HIV2-seropositive (86.7), dual HIV1 + 2-positive (100) and seronegative
mothers (92.0%). Findings suggest a higher mother-to-child transmission
rate of HIV2 in children born in Burkina Faso than in Europe and a low
clinical expression of HIV2 in children.
DE Adult Africa AIDS Serodiagnosis Cohort Studies *Disease
Transmission, Vertical Female Follow-Up Studies Human HIV
Infections/DIAGNOSIS/MORTALITY/*TRANSMISSION HIV Seroprevalence
HIV-1/*ISOLATION & PURIF HIV-2/*ISOLATION & PURIF Incidence Infant
Pregnancy Pregnancy Complications, Infectious/*VIROLOGY Prospective
Studies Support, Non-U.S. Gov't Survival Rate JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).