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1996-03-30
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Document 1105
DOCN M9651105
TI Natural history of HIV-1 infection and predictors of survival in a
cohort of HIV-1 seropositive injecting drug users.
DT 9505
AU Brown LS Jr; Siddiqui NS; Chu AF; Division of Medical Services,
Evaluation and Research, Addiction; Research and Treatment Corporation,
Brooklyn, New York 11201,; USA.
SO J Natl Med Assoc. 1996 Jan;88(1):37-42. Unique Identifier : AIDSLINE
MED/96166230
AB Injecting drug users represent a pivotal and increasing component of
acquired immunodeficiency syndrome (AIDS) case reporting in the United
States. This article describes the natural history of human
immunodeficiency virus (HIV) disease in a New York City cohort of 328
HIV-infected injecting drug users. The study sample of nearly two-thirds
men (predominately African Americans and Latino Americans) underwent
follow-up from December 1988 through December 1993. Male injecting drug
users reported a longer injecting drug use history and were more likely
to share needles/works than female injecting drug users. Eighty-nine of
328 study subjects died during the 5 years of observation. Comparing
African Americans and Latinos, race/ethnicity was not related to
survival. Survival was related to baseline CD4 count and hemoglobin
level. Zidovudine use and PCP prophylaxis did not predict survival.
Because of the continuing and increasing impact of HIV disease on
injecting drug users and communities of color, there remains an
unquestionable need to develop effective prevention programs, to
understand the natural history of HIV disease, and to develop
appropriate therapeutic interventions to treat those with HIV disease.
DE Adult CD4 Lymphocyte Count Female Human HIV
Infections/COMPLICATIONS/*EPIDEMIOLOGY/MORTALITY *HIV-1 Male Middle
Age New York City/EPIDEMIOLOGY Proportional Hazards Models
Prospective Studies *Sex Behavior Substance Abuse,
Intravenous/*COMPLICATIONS/MORTALITY Survival Analysis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).