Day 039 - 20 Oct 94 - Page 05
1 MS. STEEL: I do not think that you mentioned the very last
2 paragraph before "regulatory status", which is about some
3 consumers reporting and hyperactive children.
4
5 MR. JUSTICE BELL: No. All I am seeking to do is to pick out,
6 because I understand what is said about what I read about
7 the animal studies and the regulatory status. I can read
8 that on the page. All I am doing is looking, because it
9 interests me in the light of the extensive use of these
10 compounds and additives over a period of time. One aspect
11 for me is to see what evidence there is of adverse reaction
12 in humans.
13
14 I am not excluding the other aspects from my consideration,
15 because that is the part, it seemed to me, that you were
16 not particularly looking to but might at the end of the day
17 prove to be important. That is all.
18
19 MR. MORRIS (To the witness): Dr. Millstone, maybe if you go
20 through what you think is particularly important in your
21 statement regarding Sunset Yellow. Then I will try to see
22 how that fits into our various categories.
23 A. I think -- forgive me -- I did not write down the
24 sequence in which the categories were taken. It was?
25
26 MR. MORRIS: The first one is -----
27
28 MR. JUSTICE BELL: Have you got your statement there?
29 A. I have indeed got it, but it is not organised in that
30 particular order. If you would be kind enough to
31 indicate?
32
33 Q. Have you not got it in page order?
34 A. No, I have my statement and it is organised compound by
35 compound, but the particular headings you invited me to
36 comment under ----
37
38 MR. MORRIS: The fourth category -----?
39 A. Intolerant reaction.
40
41 Q. - intolerance, including allergies; second is
42 carcinogenicity, hyperactivity and -----
43
44 MR. JUSTICE BELL: Then you added "other long-term adverse
45 effects".
46 A. OK, fine. I will happily proceed on that basis. As
47 far as intolerant reactions are concerned, I have referred
48 in my statement, in my written statement, to a few
49 fragments of evidence indicating that Sunset Yellow has
50 been shown to provoke occasional skin eruptions in some
51 sensitive consumers. There is no information on frequency
52 in that respect.
53
54 In relation to carcinogenicity there is evidence that in
55 some laboratory animals at relatively high doses there have
56 been, apparently, significant changes at relatively high
57 doses which, on statistical analysis by comparison with
58 controls, turn out to be statistically insignificant in
59 circumstances where there was a high background incidence
60 of those tumours in both sexes in those studies.
