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1996-01-30
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Document 0001
DOCN M9610001
TI Progressive joint destruction in a human immunodeficiency virus-infected
patient with rheumatoid arthritis.
DT 9601
AU Muller-Ladner U; Kriegsmann J; Gay RE; Koopman WJ; Gay S; Chatham WW;
University of Alabama at Birmingham 35294-0006, USA.
SO Arthritis Rheum. 1995 Sep;38(9):1328-32. Unique Identifier : AIDSLINE
MED/96016065
AB This article reports the case of a 63-year-old patient with rheumatoid
arthritis (RA) whose symptoms of RA improved after the occurrence of a
secondary human immunodeficiency virus (HIV) infection; however, the HIV
infection did not affect the histologic parameters of joint destruction
to the same extent as it did the clinical symptoms. Histologic and
immunohistologic joint examinations of this patient revealed an ongoing
production of cartilage- and bone-degrading enzymes by macrophages and
fibroblasts, without the presence of T cells. These findings demonstrate
that progressive joint destruction in RA can occur in the absence of T
cells. Moreover, our results support the hypothesis that both T
cell-dependent and T cell-independent pathways play a significant role
in the pathogenesis of RA.
DE Arthritis, Rheumatoid/*COMPLICATIONS/*PATHOLOGY Case Report Human HIV
Infections/*COMPLICATIONS Immunohistochemistry Joints/*PATHOLOGY Male
Middle Age Support, Non-U.S. Gov't Synovial Membrane/PATHOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).