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M9610019.TXT
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1996-01-30
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Document 0019
DOCN M9610019
TI [Colonic Histoplasma capsulatum pseudotumor in AIDS. Morphological and
immunohistochemical diagnosis of an isolated lesion]
DT 9601
AU Hofman P; Mainguene C; Huerre M; Michiels JF; Galibert A; Caroli FX;
Loubiere R; Laboratoire d'Anatomie Pathologique, Hopital Pasteur, Nice.
SO Arch Anat Cytol Pathol. 1995;43(3):140-6. Unique Identifier : AIDSLINE
MED/96010673
AB The authors report a case of a 35-year-old man with acquired
immunodeficiency syndrome (AIDS) and a left colonic mass with
Histoplasma capsulatum (H. capsulatum). The look-up performed looking
for disseminated infection was negative. In the absence of positive
cultures, the diagnosis was determined morphologically based on the
presence of yeast observed by light and electron microscopy. The
diagnosis was also verified by positive immunofluorescence using
specific anti-Histoplasma antibodies. Gastrointestinal histoplasmosis is
a frequent complication of AIDS, particularly in some endemic areas of
America. Association with a disseminated mycotic infection is then
common. Histoplasmosis is less frequently diagnosed in Europe and
isolated involvement of the colon is exceptional. When the mycological
study is not performed or is negative, only morphological and
immunohistochemical methods are able to establish the diagnosis and
eliminate other mycotic diseases occurring during AIDS.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult AIDS-Related
Opportunistic Infections/*COMPLICATIONS/MICROBIOLOGY/ PATHOLOGY Case
Report Colonic Diseases/*COMPLICATIONS/MICROBIOLOGY/PATHOLOGY English
Abstract Histoplasma/*ISOLATION & PURIF/ULTRASTRUCTURE
Histoplasmosis/*COMPLICATIONS/MICROBIOLOGY/PATHOLOGY Human
Immunohistochemistry Male Microscopy, Electron JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).