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M9610132.TXT
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1996-01-30
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Document 0132
DOCN M9610132
TI Risk of dysplasia in anal condyloma.
DT 9601
AU Metcalf AM; Dean T; Department of Surgery, University of Iowa Hospital,
Iowa City; 52242-1086, USA.
SO Surgery. 1995 Oct;118(4):724-6. Unique Identifier : AIDSLINE
MED/96006378
AB BACKGROUND. Recent studies suggest an alarming incidence of dysplasia in
homosexuals with anal condyloma. The purpose of our study was to
determine the incidence of dysplasia in anal condyloma in our male
patients and to determine risk factors for premalignant or malignant
change. METHODS. Between 1986 and 1994, 103 male patients were referred
to our colorectal clinic for evaluation of anal condyloma. Ninety-one
patients had biopsy for pathology and form the basis of this report. All
charts were reviewed and results analyzed using the chi-squared test
with the Yates correction factor. RESULTS. Mean patient age was 31 +/-
11 years (range, 13 to 78 years) and mean duration of disease was 20 +/-
26 months (range, 2 to 120 months). There were 59 heterosexuals and 32
homosexuals/bisexuals. Two heterosexuals (3%) had invasive squamous cell
carcinoma and four (6%) had dysplasia. One homosexual/bisexual (3%) had
squamous cell carcinoma in situ and nine (28%) had dysplasia (p < 0.05).
Statistical analysis revealed that HIV seropositive status and disease
location above the dentate line also predicted increased risk of
dysplasia, whereas duration of disease, previous topical therapy,
substance abuse, and other sexually transmitted diseases were not
significant risk factors. CONCLUSIONS. Homosexual orientation, disease
above the dentate line and HIV seropositivity increase the risk of
dysplasia in perianal condyloma. The incidence of dysplasia in perianal
condyloma is significant enough to warrant consideration of biopsy in
all patients.
DE Adolescence Adult Aged Anus/*PATHOLOGY Anus
Neoplasms/*EPIDEMIOLOGY/PATHOLOGY Biopsy Carcinoma in
Situ/*EPIDEMIOLOGY Carcinoma, Squamous Cell/*EPIDEMIOLOGY Comorbidity
Condylomata Acuminata/*PATHOLOGY Epithelium/PATHOLOGY Human HIV
Infections/EPIDEMIOLOGY Male Middle Age Papillomavirus/PATHOGENICITY
Precancerous Conditions/*PATHOLOGY Retrospective Studies Sex Behavior
Sexually Transmitted Diseases/EPIDEMIOLOGY Substance Abuse/EPIDEMIOLOGY
Tumor Virus Infections JOURNAL ARTICLE REVIEW REVIEW, MULTICASE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).