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Document 0163
DOCN M9610163
TI [Clinical characteristics and natural history of human immunodeficiency
virus infection. Study in a Chilean population served at a
multiprofessional pilot center]
DT 9601
AU Wolff M; Northland R; Segovia J; Beltran C; Valdes M; Albornoz M;
Allendes G; Departamento de Medicina, Facultad de Medicina, Universidad
de; Chile, Santiago de Chile.
SO Rev Med Chil. 1995 Jan;123(1):61-73. Unique Identifier : AIDSLINE
MED/96054121
AB Four hundred and eighty six infected adults (90.7% men) were
prospectively followed from 1988 to 1993 at a multiprofessional center
in Santiago, Chile. 87.8% of male patients (pts)--84% of them
homo/bisexual--and 64.4% of women acquired the infection sexually. At
the beginning of the follow up (F/U) 51% of men and 71% of women were
asymptomatic and 30% of the total group had AIDS. (AIDS definition: CDC
1993, excluded CD4 lymphocyte count < 200 x mm3). 240/486 (49.4%) had
developed AIDS at the end of the study (12/31/93). AIDS defining events
(ADE) were: interstitial pneumonia (confirmed or suggestive as caused by
P. carinii [PCP]), 25%; tuberculosis (all forms), 22.1%; wasting, 13.8%;
Kaposi Sarcoma, 9.2%; esophageal candidiasis, 6.7%; isosporiasis, 5.4%.
Of all PCP cases, 72% were ADE, the rest, post.AIDS'. As expected, AIDS
pts continued having major complications (mainly bacterial pneumonias,
PCPs, esophagitis, tuberculosis and diarrhea due to I. belli and
Cryptosporidium. Less frequently, but also observed, were toxoplasmic
encephalitis and cryptococcal meningitis). Known mortality (excluded
abandonment of F/U) was 27% for the whole group and varied from 5.8%,
51.6% to 69.2% for the first, 4th and 6th year of F/U respectively. For
II-III CDC pts the mortality was 5% and 57% and for IV CDC pts it was
38% and 100% during the first and 6th year of F/U respectively. 36%,
53%, 74% and 85% of the pts followed for 1, 3, 5 and 6 years
respectively had developed AIDS by the end of 1993. Multifactorial
causes with either diarrhea, wasting or both were responsible for the
death in half the pts in whom this was known, 15% died of respiratory
complications and 5.7% of cryptococcal meningitis. 80% of AIDS pts
survived their ADE. This study has provided information about the
clinical profile of the HIV infection and natural history of the disease
in Chile.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/*DIAGNOSIS/
MORTALITY/TRANSMISSION Adult Chile/EPIDEMIOLOGY Community Health
Centers English Abstract Female Follow-Up Studies Human HIV
Infections/COMPLICATIONS/*DIAGNOSIS/MORTALITY/TRANSMISSION Male Middle
Age Patient Care Team Pilot Projects Prospective Studies Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).