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1996-01-30
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Document 0168
DOCN M9610168
TI Bronchiolitis obliterans organizing pneumonia.
DT 9601
AU Epler GR; Department of Medicine, New England Baptist Hospital, Boston,
MA; 02120, USA.
SO Semin Respir Infect. 1995 Jun;10(2):65-77. Unique Identifier : AIDSLINE
MED/96047398
AB Bronchiolitis obliterans organizing pneumonia (BOOP) is increasingly
recognized as an important cause of diffuse infiltrative lung disease.
It is a diagnostic consideration in patients with a febrile flu-like
illness of a few weeks' duration and a roentgenogram showing bilateral
patchy infiltrates that are not responsive to a typical course of
antibiotics. It is defined as granulated tissue plugs within lumens of
small airways that extend into alveolar ducts and alveoli. Clinically, a
flu-like illness, cough, and crackles are common. Pulmonary function
studies of patients show a decreased vital capacity, normal flow rates
(except in smokers), and a decreased diffusing capacity. It is generally
idiopathic, but it may occur during the resolution of a viral or
mycoplasma pneumonia. It is also associated with a variety of systemic
illnesses and clinical settings. These include the connective tissue
disorders, antineoplastic and other drugs, and immunological disorders,
as well as bone marrow and lung transplantation. There are numerous
related disorders, including human immunodeficiency virus infection,
radiation therapy, thyroiditis, and alcoholic cirrhosis. In idiopathic
BOOP, complete resolution occurs in 65% to 85% of patients treated with
corticosteroid therapy. This type of therapy is often effective in
patients with associated systemic disorders or in other clinical
settings, but there may be limited or no response in patients with
dermatomyositis, immunosuppression, or interstitial opacities at the
lung bases. Respiratory failure leading to death may occur in 5% of
patients. It is important to add BOOP to the differential diagnosis of
febrile, noninfectious illnesses that are mimics of pneumonia.
DE Adult Arthritis, Rheumatoid/COMPLICATIONS Bone Marrow
Transplantation/ADVERSE EFFECTS Bronchiolitis Obliterans Organizing
Pneumonia/CLASSIFICATION/ *DIAGNOSIS/ETIOLOGY Connective Tissue
Diseases/COMPLICATIONS Diagnosis, Differential Female Human
Immunologic Diseases/COMPLICATIONS Lung/PATHOLOGY Lung
Transplantation/ADVERSE EFFECTS Male Middle Age Pneumonia/DIAGNOSIS
Pneumonia, Mycoplasma/COMPLICATIONS Pneumonia, Viral/COMPLICATIONS
Thoracic Radiography Tomography, X-Ray Computed JOURNAL ARTICLE
REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).