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1996-01-30
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Document 0224
DOCN M9610224
TI [Isolation of an acid-alcohol resistant bacillus (BAAR) in the febrile
HIV infected patients: Mycobacterium tuberculosis (MT) or Mycobacterium
avium complex (MAC)?]
DT 9601
AU Brel F; Rabaud C; May T; Hoen B; Amiel C; Burty C; Dailloux M; Canton P;
Service des Maladies Infectieuses et Tropicales, Hopitaux de; Brabois,
Vandceuvre, France.
SO Pathol Biol (Paris). 1995 Apr;43(4):380-4. Unique Identifier : AIDSLINE
MED/96008857
AB The detection of BAAR in HIV infected patients with CD4 < 100/mm3 and
with an infectious syndrome urge on beginning an effective treatment
against Mycobacterium tuberculosis and/or Mycobacterium avium Complex,
before the results of the culture are known. Our purpose was to search
clinical and biological features to angle directly the diagnosis towards
a tuberculosis or not, and to start the most suitable treatment. This
retrospective study, from 1986 to 1993, stated on 54 patients who had at
least one sample with positive BAAR (blood, marrow, stools, sputum or
urine cultures). From these cultures, MAC was isolated on 37 patients
and BK on 17. The both groups were similar for age, sex, risk factor,
number of opportunistic infections, delay between the date of AIDS and
the discovery of a positive BAAR, and Ag p24. However, a significant
difference in favor of a MAC disease exists regarding about:
disseminated infections (92% vs 53%), digestive troubles (57% vs 23.5%),
anterior or concomitant CMV infection (49% vs 9%), isolation of BAAR in
blood culture (54% vs 20%) or in stools culture (76% vs 33%), leucopenia
(2850/mm3 +/- 1520 vs 4124/mm3 +/- 2232), anemia (Hb 9.1 g/dl +/- 1.5 vs
10.1 g/dl +/- 1.6). The univariated analysis of results allowed us to
conclude that the presence of one among those parameters must induce the
prescription of a suitable treatment against MAC.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult AIDS-Related
Opportunistic Infections/*COMPLICATIONS/MICROBIOLOGY English Abstract
Female Human HIV Infections/*COMPLICATIONS/MICROBIOLOGY Male
Mycobacterium avium-intracellulare Infection/*COMPLICATIONS/
MICROBIOLOGY Retrospective Studies
Tuberculosis/*COMPLICATIONS/MICROBIOLOGY Tuberculosis,
Pulmonary/*COMPLICATIONS/MICROBIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).