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M9610291.TXT
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1996-01-30
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Document 0291
DOCN M9610291
TI Adult T cell leukemia following HTLV-I-associated myelopathy/tropical
spastic paraparesis: case reports and implication to the natural course
of ATL.
DT 9601
AU Tamiya S; Matsuoka M; Takemoto S; Shimizu K; Yamaguchi K; Mita S; Uchino
M; Ando M; Miyaguni T; Kuniyoshi K; et al; Second Department of Internal
Medicine, Kumamoto University; School of Medicine, Japan.
SO Leukemia. 1995 Oct;9(10):1768-70. Unique Identifier : AIDSLINE
MED/96013980
AB Adult T cell leukemia (ATL) is the T cell malignancy caused by human T
lymphotropic virus type I (HTLV-I), and HTLV-I is also the causative
agent of HTLV-I-associated myelopathy/tropical spastic paraparesis
(HAM/TSP). Although HTLV-I causes both diseases, concomitant occurrence
is reported to be rare. This paper describes two cases of HAM/TSP that
developed into lymphoma-type ATL after the onset of HAM/TSP. In one
case, the same HTLV-I infected clone could be detected by polymerase
chain reaction in peripheral blood obtained when the patient was
diagnosed as HAM/TSP. This finding showed that the HTLV-I clone already
existed at the stage of HAM/TSP. Since frequent detection of clonal
proliferation of HTLV-I infected cells has been reported previously in
patients with HAM/TSP, careful follow-up is needed for patients with
HAM/TSP.
DE Base Sequence Case Report Disease Progression Female Human
HTLV-I/GENETICS/*ISOLATION & PURIF Leukemia, T-Cell/PATHOLOGY/*VIROLOGY
Male Middle Age Molecular Sequence Data Paraparesis, Tropical
Spastic/PATHOLOGY/*VIROLOGY Polymerase Chain Reaction Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).