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1996-01-30
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Document 0340
DOCN M9610340
TI Loss of periodontal attachment in HIV-seropositive military personnel.
DT 9601
AU Tomar SL; Swango PA; Kleinman DV; Burt BA; Centers for Disease Control
and Prevention, Atlanta, GA, USA.
SO J Periodontol. 1995 Jun;66(6):421-8. Unique Identifier : AIDSLINE
MED/96023910
AB The cross-sectional relationship between severe loss of periodontal
attachment (LPA) and worsening immune status due to HIV infection was
evaluated in 474 HIV-infected subjects (416 men, 58 women) aged 18 to 49
years who had been classified at stages 1 through 6 of the Walter Reed
Army Institute of Research (WR) Staging Classification System. LPA was
measured at four sites per tooth using a manual probe; severe LPA was
defined as > or = 1 site/subject exhibiting > or = 5 mm LPA. Severe LPA
was found in 94 (20%) of the subjects. Modeling with multiple logistic
regression analysis revealed that WR stage and peripheral CD4+
lymphocyte cell counts were not significant independent predictors of
severe LPA. Severe LPA was more common in subjects at WR stage 5 or 6
who exhibited oral candidiasis (OC), a marker of immune system damage,
than in persons at those WR stages without OC (odds ratio = 7.85; 95%
confidence interval (CI) = 1.94-31.81). After the analysis controlled
for WR stage, younger subjects receiving AZT had greater odds of severe
LPA than same-age subjects not taking the drug (e.g., odds ratio for
subjects aged 30 years = 2.59; 95% CI = 1.22, 5.49). Other significant
predictors in the model included male sex; retired military status;
cigarette smoking; and presence of cratered, ulcerated, or necrotic
interdental papillae. HIV-associated immune deficiency may be associated
with localized severe LPA, but this may be an indirect association due
to medication use, opportunistic infection, or other factors not
captured by the WR staging system or peripheral CD4+ cell
counts.(ABSTRACT TRUNCATED AT 250 WORDS)
DE Adolescence Adult Age Factors Antiviral Agents/THERAPEUTIC USE
AIDS-Related Opportunistic Infections/COMPLICATIONS Candidiasis,
Oral/COMPLICATIONS Cross-Sectional Studies CD4 Lymphocyte Count
Female Forecasting Gingival Diseases/COMPLICATIONS Human HIV
Infections/CLASSIFICATION/COMPLICATIONS/DRUG THERAPY HIV
Seropositivity/CLASSIFICATION/*COMPLICATIONS/DRUG THERAPY Logistic
Models Male Middle Age *Military Personnel Odds Ratio Periodontal
Attachment Loss/CLASSIFICATION/*COMPLICATIONS Sex Factors
Smoking/ADVERSE EFFECTS Support, U.S. Gov't, P.H.S.
Zidovudine/THERAPEUTIC USE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).