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- Document 0340
- DOCN M9610340
- TI Loss of periodontal attachment in HIV-seropositive military personnel.
- DT 9601
- AU Tomar SL; Swango PA; Kleinman DV; Burt BA; Centers for Disease Control
- and Prevention, Atlanta, GA, USA.
- SO J Periodontol. 1995 Jun;66(6):421-8. Unique Identifier : AIDSLINE
- MED/96023910
- AB The cross-sectional relationship between severe loss of periodontal
- attachment (LPA) and worsening immune status due to HIV infection was
- evaluated in 474 HIV-infected subjects (416 men, 58 women) aged 18 to 49
- years who had been classified at stages 1 through 6 of the Walter Reed
- Army Institute of Research (WR) Staging Classification System. LPA was
- measured at four sites per tooth using a manual probe; severe LPA was
- defined as > or = 1 site/subject exhibiting > or = 5 mm LPA. Severe LPA
- was found in 94 (20%) of the subjects. Modeling with multiple logistic
- regression analysis revealed that WR stage and peripheral CD4+
- lymphocyte cell counts were not significant independent predictors of
- severe LPA. Severe LPA was more common in subjects at WR stage 5 or 6
- who exhibited oral candidiasis (OC), a marker of immune system damage,
- than in persons at those WR stages without OC (odds ratio = 7.85; 95%
- confidence interval (CI) = 1.94-31.81). After the analysis controlled
- for WR stage, younger subjects receiving AZT had greater odds of severe
- LPA than same-age subjects not taking the drug (e.g., odds ratio for
- subjects aged 30 years = 2.59; 95% CI = 1.22, 5.49). Other significant
- predictors in the model included male sex; retired military status;
- cigarette smoking; and presence of cratered, ulcerated, or necrotic
- interdental papillae. HIV-associated immune deficiency may be associated
- with localized severe LPA, but this may be an indirect association due
- to medication use, opportunistic infection, or other factors not
- captured by the WR staging system or peripheral CD4+ cell
- counts.(ABSTRACT TRUNCATED AT 250 WORDS)
- DE Adolescence Adult Age Factors Antiviral Agents/THERAPEUTIC USE
- AIDS-Related Opportunistic Infections/COMPLICATIONS Candidiasis,
- Oral/COMPLICATIONS Cross-Sectional Studies CD4 Lymphocyte Count
- Female Forecasting Gingival Diseases/COMPLICATIONS Human HIV
- Infections/CLASSIFICATION/COMPLICATIONS/DRUG THERAPY HIV
- Seropositivity/CLASSIFICATION/*COMPLICATIONS/DRUG THERAPY Logistic
- Models Male Middle Age *Military Personnel Odds Ratio Periodontal
- Attachment Loss/CLASSIFICATION/*COMPLICATIONS Sex Factors
- Smoking/ADVERSE EFFECTS Support, U.S. Gov't, P.H.S.
- Zidovudine/THERAPEUTIC USE JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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