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1996-01-30
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Document 0363
DOCN M9610363
TI Detection of several types of human papilloma viruses in AIDS-associated
Kaposi's sarcoma.
DT 9601
AU Adams V; Kempf W; Hassam S; Briner J; Schmid M; Moos R; Pfaltz M;
Department of Pathology, University of Zurich, Switzerland.
SO J Med Virol. 1995 Jul;46(3):189-93. Unique Identifier : AIDSLINE
MED/96028706
AB Epidemiological studies indicate that acquired immunodeficiency syndrome
(AIDS)-associated Kaposi's sarcoma (KS) may be caused by an infectious,
preferentially sexually transmitted agent. Infections with human
papilloma viruses are common, sexually transmitted diseases occurring
frequently in homosexual men, who are also the main risk group for
developing KS. In order to evaluate the possible role of HPV in the
development of KS, 24 cutaneous AIDS-associated Kaposi's sarcomas were
investigated by the polymerase chain reaction (PCR) and by in situ
hybridization for the presence of human papilloma viruses (HPV). HPV DNA
sequences were detected in 5 of 24 KS specimens, in 4 of 13 normal skin
specimens from AIDS patients without KS and in 5 of 14 skin specimens of
HIV-seronegative patients. For the first time, HPV types 6 and 33 were
detected by PCR in KS. A higher proportion of HPV types 16/18 was found
in AIDS-associated KS specimens, whereas HPV type 33 was seen more often
in normal skin specimens of the control group. Apart from the known HPV
types 16/18 described in KS, this study demonstrates also the presence
of HPV 6 and 33 in this condition.
DE Adult Aged AIDS-Related Opportunistic
Infections/COMPLICATIONS/*VIROLOGY Base Sequence DNA Primers DNA,
Viral/ANALYSIS Human In Situ Hybridization Male Middle Age
Molecular Sequence Data Papillomavirus, Human/CLASSIFICATION/*ISOLATION
& PURIF Papovaviridae Infections/COMPLICATIONS/PATHOLOGY/*VIROLOGY
Sarcoma, Kaposi's/COMPLICATIONS/PATHOLOGY/*VIROLOGY Tumor Virus
Infections/COMPLICATIONS/PATHOLOGY/*VIROLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).