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M9610495.TXT
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1996-01-30
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Document 0495
DOCN M9610495
TI [Pregnancies in HIV infected women in Switzerland]
DT 9601
AU Biedermann K; Rudin C; Irion O; Spoletini G; Lauper U; Kind C;
Kantonales Frauenspital Fontana, Chur.
SO Geburtshilfe Frauenheilkd. 1995 Aug;55(8):447-55. Unique Identifier :
AIDSLINE MED/96024309
AB In a national multicentre study, 229 pregnancies in 219 HIV-positive
women were prospectively followed up between January 1, 1990, and
October 30, 1993. 69.8% were infected by intravenous drug abuse and
91.5% were asymptomatic (CDC classes II and III) in early pregnancy. 48
(21.0%) were first discovered to be HIV-infected during the index
pregnancy: 46 of these had risk factors. The present epidemiologic
development does not seem to warrant a general HIV-screening in
pregnancy at this time. 71 pregnancies (31%) were terminated; 158
children were born, 17 (23.3%) of the 73 definitely classified are
HIV-infected. An asymptomatic HIV infection with a sufficiently high (>
200/microliters) CD4 cell count has no proven influence on the
pregnancy. Otherwise, however, maternal infectious diseases can lead to
prematurity. For mothers with i.v. drug abuse, there is a significantly
higher incidence of prematurity and fetal growth retardation. The
maternal HIV infection can be transmitted to the child either during
pregnancy or at delivery. The incidence of vertical transmission in our
study was 23.3%; the most predictive parameter for a prenatal HIV
transmission is a low anti-p24 antibody titre. The risk of intrapartum
transmission seems to be somewhat, but not significantly, reduced for
primary Caesarean sections. Recently, prophylaxis with Zidovudin during
pregnancy, beginning after the 14th GW, was found to reduce vertical
HIV-transmission by 66%. Since the virus can also be transmitted through
mothers' milk, HIV-positive mothers should not nurse their babies.
Maternal infections are significantly more frequent in HIV-positive
women, and are a risk factor for prematurity.(ABSTRACT TRUNCATED AT 250
WORDS)
DE Abortion, Induced/STATISTICS & NUMER DATA Adult Cesarean
Section/STATISTICS & NUMER DATA Cross-Sectional Studies CD4 Lymphocyte
Count/DRUG EFFECTS Disease Transmission, Vertical/PREVENTION & CONTROL
English Abstract Female Human HIV
Infections/*EPIDEMIOLOGY/TRANSMISSION *HIV-1 Incidence Infant,
Newborn Mass Screening Pregnancy Pregnancy Complications,
Infectious/*EPIDEMIOLOGY/ETIOLOGY Pregnancy Outcome Risk Factors
Substance Abuse, Intravenous/COMPLICATIONS/EPIDEMIOLOGY Support,
Non-U.S. Gov't Switzerland/EPIDEMIOLOGY Zidovudine/ADMINISTRATION &
DOSAGE/ADVERSE EFFECTS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).