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1996-01-30
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Document 0635
DOCN M9610635
TI Longitudinal immunological follow-up of HIV infected haemophiliacs in
Hungary.
DT 9601
AU Ujhelyi E; Krall G; Zimonyl I; Banhegyi D; Hollan SR; Horvath A; Fuchs
D; Wachter H; Berkessy E; Fust G; National Institute of Haematology,
Blood Transfusion and; Immunology, Budapest, Hungary.
SO Acta Microbiol Immunol Hung. 1995;42(2):189-98. Unique Identifier :
AIDSLINE MED/96044930
AB Twenty-five haemophiliacs who had been infected with HIV in 1982 or 1983
were followed up from 1986 to 1993. The absolute number of the CD4+ and
CD8+ cells, neopterin levels and more recently the percentage of
activated, DR+ T lymphocytes were determined twice a year. In most
patients a permanent decline in the CD4+ cell count was observed whereas
in two HIV-infected haemophiliacs the absolute number of CD4+ cells did
not change during the observation period. In these long-term
non-progressor patients no clinical symptoms and no increased neopterin
levels were observed. T cells subset and neopterin measurements were
found to predict the development of AIDS. AIDS developed only in those
patients who exhibited both a CD4+ cell count of < 350/microliter and a
serum neopterin concentration of > 20 nmol/l. A negative correlation was
observed between the percentage of activated. DR+ T lymphocytes and the
CD4+ cell counts.
DE Adolescence Adult Antigens, CD3/BIOSYNTHESIS Biopterin/ANALOGS &
DERIVATIVES/BIOSYNTHESIS Case-Control Studies Child CD4-CD8 Ratio
CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive
T-Lymphocytes/IMMUNOLOGY Follow-Up Studies
Hemophilia/COMPLICATIONS/*IMMUNOLOGY/METABOLISM Human Hungary HIV
Seronegativity/IMMUNOLOGY HIV
Seropositivity/COMPLICATIONS/*IMMUNOLOGY/METABOLISM Lymphocyte
Subsets/IMMUNOLOGY Lymphocyte Transformation Middle Age Predictive
Value of Tests JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).