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M9610644.TXT
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1996-01-30
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Document 0644
DOCN M9610644
TI MF59. Design and evaluation of a safe and potent adjuvant for human
vaccines.
DT 9601
AU Ott G; Barchfeld GL; Chernoff D; Radhakrishnan R; van Hoogevest P; Van
Nest G; Chiron Corporation, Emeryville, California 94608, USA.
SO Pharm Biotechnol. 1995;6:277-96. Unique Identifier : AIDSLINE
MED/96057688
AB MF59 is a safe, practical, and potent adjuvant for use with human
vaccines. The formulation is easily manufactured, may be sterilized by
filtration, and is both compatible and efficacious with all antigens
tested to date. MF59 has been shown to be a potent stimulator of
cellular and humoral responses to subunit antigens in both animal models
and clinical studies. Toxicology studies in animal models and Phase
I-III studies in humans have demonstrated the safety of MF59 with HSV,
HIV, and influenza vaccines.
DE Adjuvants, Immunologic/CHEMISTRY/*CHEMICAL SYNTHESIS Animal Drug
Design Emulsions Human Polysorbates/CHEMISTRY/*CHEMICAL SYNTHESIS
Squalene/CHEMISTRY/*CHEMICAL SYNTHESIS/IMMUNOLOGY
Vaccines/ADMINISTRATION & DOSAGE/IMMUNOLOGY JOURNAL ARTICLE REVIEW
REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).