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M9610679.TXT
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1996-01-30
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Document 0679
DOCN M9610679
TI [The clinical and immunological correlations between the p24 antigenemia
levels and those of anti-p24 antibodies in HIV-seropositive children]
DT 9601
AU Apetrei C; Buzdugan I; Mitroi I; Duca M; Laboratorul de Virologie,
U.M.F. Iasi.
SO Bacteriol Virusol Parazitol Epidemiol. 1995 Apr-Jun;40(2):141-4. Unique
Identifier : AIDSLINE MED/96029120
AB The influence of HIV I p24 antigen immune complexing with anti-p24
antibodies of the assessment of their respective levels in HIV-positive
sera was studied. ELISA tests were used for evaluating anti-p24 and p24
antigenemia, with or without acid dissociation. We have observed that:
1. p24 antigenemia usually coexisted with low anti-p24 levels, an
inverse correlation between these two parameters being traced; acid
dissociation increased the percentage of p24 positive sera, especially
when anti-p24 titers are low; 2. on contrary, after acid dissociation,
p24 Ag remain undetectable in 55.56% of patients presenting high titers
and 29.41% of those with low levels of anti-p24; acid dissociation do
not increase anti-p24 titers. Whereas the first group of observations
suggests that p24 Ag and anti-p24 Ab may be involved in immune
complexes, the second set indicates that p24 Ag and Ab were not
inevitably linked in such complexes. So, they may be indicative for two
distinct biological phenomena.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY Chi-Square Distribution
Child English Abstract Enzyme-Linked Immunosorbent
Assay/METHODS/STATISTICS & NUMER DATA Human HIV Antibodies/*BLOOD HIV
Core Protein p24/*BLOOD/IMMUNOLOGY HIV Seropositivity/*IMMUNOLOGY
HIV-1/*IMMUNOLOGY Regression Analysis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).