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Document 0687
DOCN M9610687
TI Cell death in health and disease: the biology and regulation of
apoptosis.
DT 9601
AU Bellamy CO; Malcomson RD; Harrison DJ; Wyllie AH; Department of
Pathology, University Medical School, Edinburgh,; UK.
SO Semin Cancer Biol. 1995 Feb;6(1):3-16. Unique Identifier : AIDSLINE
MED/96037771
AB Apoptosis is a morphologically stereotyped form of cell death, prevalent
in multicellular organisms, by which single cells are deleted from the
midst of living tissues. Recognition of the cellular corpses and their
removal by phagocytosis occurs without disturbance to tissue
architecture or function and without initiating inflammation. Apoptosis
is regulable and is of fundamental importance to tissue development and
homeostasis. Cellular susceptibility to apoptosis is determined by a
variety of signals, of both extracellular and internal origin, including
proliferative status. Dysregulated apoptosis is important in the
pathogenesis of several important human diseases including neoplasia,
and recognition of the defects involved is prompting development of new
therapeutic strategies.
DE Acquired Immunodeficiency Syndrome/PATHOLOGY Animal
Apoptosis/*PHYSIOLOGY Cell Death/PHYSIOLOGY Human
Inflammation/PATHOLOGY Neoplasms/PATHOLOGY Neoplasms,
Experimental/PATHOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).