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M9610703.TXT
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1996-01-30
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Document 0703
DOCN M9610703
TI Human T lymphotropic virus type I-associated myelopathy/tropical spastic
paraparesis in Sao Paulo, Brazil.
DT 9601
AU Domingues RB; Muniz MR; Pinho JR; Bassit L; Jorge ML; Alquezar AS;
Marchiori PE; Chamone DF; Scaff M; Department of Neurology, University
of Sao Paulo School of; Medicine, Brazil.
SO Clin Infect Dis. 1995 Jun;20(6):1540-2. Unique Identifier : AIDSLINE
MED/96034948
AB We conducted a prospective clinical and epidemiologic evaluation of 45
cases of human T lymphotropic virus type I (HTLV-1)-associated
myelopathy/tropical spastic paraparesis (HAM/TSP) in Sao Paulo, Brazil.
All enrolled patients had progressive chronic myelopathy and high titers
of HTLV-I and HTLV-II antibodies, as determined by enzyme immunoassay
and western blot. In 24 cases, the polymerase chain reaction (PCR) was
performed so that HTLV-I could be distinguished from HLTV-II. The
clinical and epidemiologic features of the patients from our study were
similar to those of patients with HAM/TSP from other areas of endemicity
for HTLV-I except that more patients in our study had received a blood
transfusion prior to their illness. Despite the presence of HTLV-II
virus in Brazil, all patients whose serum was tested by PCR were found
to be infected with the HTLV-I virus.
DE Adult Aged Brazil/EPIDEMIOLOGY Female Human HTLV-BLV
Antibodies/BLOOD HTLV-I/ISOLATION & PURIF HTLV-II/ISOLATION & PURIF
Male Middle Age Paraparesis, Tropical Spastic/*EPIDEMIOLOGY/VIROLOGY
Polymerase Chain Reaction Prospective Studies JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).