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1996-01-30
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Document 0704
DOCN M9610704
TI Injection drug use and human immunodeficiency virus infection.
DT 9601
AU Alcabes P; Friedland G; Yale University AIDS Program, New Haven,
Connecticut 06510, USA.
SO Clin Infect Dis. 1995 Jun;20(6):1467-79. Unique Identifier : AIDSLINE
MED/96034936
AB In this paper we discuss the epidemiology and natural history of human
immunodeficiency virus (HIV) infection in users of injection drugs. Use
of injection drugs plays a central role in the HIV infection/AIDS
epidemic in the United States, Europe, and many parts of the developing
world. The significance of this role has been underappreciated until
quite recently because of a number of factors. One factor has been
systematic, albeit inadvertent, underreporting of cases of HIV disease
and AIDS in drug injectors as a consequence of the initially narrow
surveillance case definition for AIDS. A measure of this phenomenon has
been the disproportionately larger increment of new cases in this
population with each successive revision of the Centers for Disease
Control and Prevention's surveillance case definition for AIDS. Other
reasons for the underappreciation of the magnitude and consequences of
HIV infection and AIDS in injection drug users include the lack of
necessary diagnostic facilities in the institutions where drug users are
often treated, high mortality rates among HIV-infected drug users for
whom a diagnosis of AIDS has not yet been made, the severe
marginalization of this population and its lack of advocates, and the
localization of the initial epidemic in this population to certain
geographic areas.
DE Human HIV Infections/COMPLICATIONS/EPIDEMIOLOGY/PHYSIOPATHOLOGY/
*TRANSMISSION Risk Factors Substance Abuse, Intravenous/*COMPLICATIONS
JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).