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M9610790.TXT
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1996-01-30
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Document 0790
DOCN M9610790
TI Recurrent transient neurological deficits in advanced HIV infection.
DT 9601
AU Baily GG; Mandal BK; Department of Infectious Diseases and Tropical
Medicine, North; Manchester General Hospital, UK.
SO AIDS. 1995 Jul;9(7):709-12. Unique Identifier : AIDSLINE MED/96035233
AB OBJECTIVES: To report the occurrence of a syndrome of recurrent
neurological deficits in advanced HIV disease and to discuss its
management and prognosis. DESIGN: Retrospective case study. SETTING: A
regional treatment centre for HIV-infected individuals in northwest
England. MAIN OUTCOME MEASURES: Transient neurological deficit was
defined as a focal neurological deficit of rapid onset which resolved
completely within 24 h. Frequency, character and duration of episodes
were recorded. Prior illnesses, CD4 count, changes in drug therapy and
brain imaging investigations were also documented. RESULTS: Seven cases
with recurrent transient neurological deficits were identified among 748
patients over a 10-year period. Six had a CD4 cell count < 50 x 10(6)/l.
The episodes lasted between 1 and 12 h and resolved completely without
lasting sequelae. Dysphasia and hemiparesis were the most common
presentations. Recurrent episodes for each patient tended to follow a
similar pattern. None had computed tomographic evidence of cerebral
infarction or clinical evidence of completed stroke. Prognosis was
varied and not evidently altered by the episodes of neurological
deficit. Three patients may have benefited from treatment with migraine
prophylactics. CONCLUSION: A syndrome of recurrent transient
neurological deficits may occur in advanced HIV disease. We believe that
in some cases this may be due to local cerebral vasospasm, comparable to
a classic migraine aura.
DE Adult Case Report Human HIV Infections/*COMPLICATIONS/PATHOLOGY Male
Nervous System Diseases/*ETIOLOGY Recurrence JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).